884660-47-3

Usage

Uses

Used in Pharmaceutical Industry:
6-fluoro-5-iodopyridin-2-aMine is utilized as a building block for the synthesis of a variety of pharmaceuticals and agrochemicals. Its presence in these compounds is attributed to its ability to contribute specific structural and functional attributes that are beneficial for the development of new drugs.
Used in Organic Chemistry:
In the field of organic chemistry, 6-fluoro-5-iodopyridin-2-aMine serves as a reagent for introducing fluorine and iodine atoms into different organic molecules. This capability is crucial for the creation of novel organic compounds with tailored properties.
Used in Drug Discovery and Development:
6-fluoro-5-iodopyridin-2-aMine is also employed as a starting material for the preparation of various functionalized pyridine derivatives. These derivatives hold potential applications in drug discovery and development, where they can be optimized for specific therapeutic targets or to improve the pharmacokinetic and pharmacodynamic profiles of drug candidates.
Overall, 6-fluoro-5-iodopyridin-2-aMine is a versatile chemical entity with applications spanning across multiple scientific disciplines, particularly in the creation and enhancement of pharmaceutical agents and organic compounds.

Upstream product

• 884660-46-2 N-(6-fluoro-5-iodopyridin-2-yl)acetamide 
• 856851-34-8 2,6-diamino-3-iodopyridine 
• 884660-45-1 N-(6-amino-5-iodopyridin-2-yl)acetamide 
• 141-86-6 2.6-diaminopyridine 
• 1597-32-6 6-fluoro-pyridin-2-ylamine 

Downstream Products

• 884660-48-4 2-fluoro-6-hydroxy-3-iodopyridine 
• 884660-49-5 6-(2-(4-nitrophenyl)ethoxy)-2-fluoro-3-iodopyridine 
• 884660-53-1 6-[2-(4-nitrophenyl)ethoxy]-3-(β-D-glycero-pentofuran-3'-ulos-1'-yl)-2-fluoropyridine 
• 884660-56-4 3-[2-deoxy-β-D-erythro-pentafuranosyl]-2-fluoro-6-[2-(4-nitrophenyl)ethoxy]pyridine 

Relevant academic research and scientific papers

NOVEL CRYSTAL OF (3S)-3-[2-(6-AMINO-2-FLUOROPYRIDINE-3-YL)-4-FLUORO-1H-IMIDAZOLE-5-YL]-7-[5-CHLORO-2-(1H-TETRAZOLE-1-YL)PHENYL]-2,3-DIHYDROINDOLIZINE-5(1H)-ONE

Provided is a novel crystal form of (3S)-3-[2-(6-amino-2-fluoropyridin-3-yl)-4-fluoro-1H-imidazol-5-yl]-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2,3-dihydroindolizin-5(1H)-one. Provided is (3S)-3-[2-(6-amino-2-fluoropyridin-3-yl)-4-fluoro-1H-imidazol-5-yl]-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2,3-dihydroindolizin-5(1H)-one-3-hydroxybenzoic acid (1/1).

KIF18A INHIBITORS

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

HETEROARYL COMPOUNDS AND USES THEREOF

Described herein are compounds of formula (I), and pharmaceutically acceptable salts, solvates, hydrates, isotopically labeled derivatives and radiolabeled derivative thereof, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for detecting and imaging Tau aggregates in the brain for detection of Alzheimer's disease (AD) in a subject.

DIHYDROINDOLIZINONE DERIVATIVE

A compound represented by general formula (I) (wherein all symbols are as defined in the description) or a salt, solvate, N-oxide form or prodrug thereof is a potent FXIa inhibitor, has excellent oral absorption properties and kinetics in blood, can exert a potent anti-coagulation activity over a long period of time after being administered orally, and has a discrepancy between the anti-coagulation activity thereof and the CYP-inhibiting activity thereof. Therefore, the compound or the salt, solvate, N-oxide form or prodrug thereof can be used as an efficient prophylactic and/or therapeutic agent for vascular occlusive diseases.

Syntheses of pyridine C-nucleosides as analogues of the natural nucleosides dC and dU

The syntheses of four pyrimidine C-nucleosides are described. These derivatives are designed as mimics of dC and dU, and in that respect, each can form two hydrogen bonds with complementary dG or dA residues. The minor groove O2 carbonyl in each derivativ