884875-42-7

Upstream product

• 4572-03-6 3-(N-methylpiperazino)propylamine 
• 934464-03-6 [3-(4-methyl-piperazin-1-yl)-propyl]-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine 
• 50529-33-4 3-chloro-4-fluorophenyl isocyanate 

Downstream Products

• 884875-57-4 1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea 

Relevant academic research and scientific papers

Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists

Melanin concentrating hormone (MCH) plays an important role in the regulation of food intake and energy balance in mammals. MCH-1 receptor (MCH1R) deficient mice are lean and resistant to diet-induced obesity. As such, MCH1R antagonists are believed to ha

BICYCLIC COMPOUNDS AS SELECTIVE MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS

The present invention discloses compounds of Formula I [CHEMICAL FORMULA should be inserted here as it appears in abstract in paper form] Formula I wherein V, W, Y, Z, R1, R2, R3, R4, d, m, n, p and r are herein defined, said compounds being novel antagon