3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

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Chemical Name:3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea
CAS No.:884875-42-7
Molecular Formula:C₂₅H₃₁ClFN₅O₃
Molecular Weight:504.004
Hs Code.:

Synonyms:3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

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Chemical Property of 3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

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Technology Process of 3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

There total 4 articles about 3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 934464-03-6
[3-(4-methyl-piperazin-1-yl)-propyl]-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine

: 50529-33-4
3-chloro-4-fluorophenyl isocyanate

: 884875-42-7
3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2006.12.080

Reference yield:

: 4572-03-6
3-(N-methylpiperazino)propylamine

: 884875-42-7
3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

Guidance literature:: Multi-step reaction with 3 steps

1: Ti(O-i-Pr)4 / 3 h / 80 °C

2: NaBH₄ / methanol / 12 h / 0 - 20 °C

3: 48 percent / i-Pr₂NEt / CH₂Cl₂

With titanium(IV) isopropylate; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.12.080

Reference yield:

: [3-(4-methyl-piperazin-1-yl)-propyl]-(7-nitro-3,4-dihydro-1H-naphthalen-2-ylidene)-amine

: 884875-42-7
3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / methanol / 12 h / 0 - 20 °C

2: 48 percent / i-Pr₂NEt / CH₂Cl₂

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.12.080