884902-61-8Relevant academic research and scientific papers
Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP
Fraley, Mark E.,Garbaccio, Robert M.,Arrington, Kenneth L.,Hoffman, William F.,Tasber, Edward S.,Coleman, Paul J.,Buser, Carolyn A.,Walsh, Eileen S.,Hamilton, Kelly,Fernandes, Christine,Schaber, Michael D.,Lobell, Robert B.,Tao, Weikang,South, Victoria J.,Yan, Youwei,Kuo, Lawrence C.,Prueksaritanont, Thomayant,Shu, Cathy,Torrent, Maricel,Heimbrook, David C.,Kohl, Nancy E.,Huber, Hans E.,Hartman, George D.
, p. 1775 - 1779 (2007/10/03)
The evolution of 2,4-diaryl-2,5-dihydropyrroles as inhibitors of KSP is described. Introduction of basic amide and urea moieties to the dihydropyrrole nucleus enhanced potency and aqueous solubility, simultaneously, and provided compounds that caused mito
Prodrugs of mitotic kinesin inhibitors
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Page/Page column 42-43, (2008/06/13)
The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention
MITOTIC KINESIN INHIBITORS
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Page 183, (2008/06/13)
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions
MITOTIC KINESIN INHIBITORS
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Page 67-68, (2010/02/04)
The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to composition
