885-24-5

Usage

Uses

Used in Pharmaceutical Industry:
ASISCHEM R26543 is used as an intermediate in the synthesis of Divin, which is an inhibitor of bacterial cell division. This makes it a valuable compound in the development of new antibiotics to combat bacterial infections.
Used in Chemical Synthesis:
ASISCHEM R26543 is also used in the synthesis of adipic dihydrazones, which exhibit anti-bacterial activity. This application highlights its potential use in creating new compounds with therapeutic properties for treating bacterial infections.

InChI:InChI=1/C14H14O2/c1-10(2)16-14-8-7-11-5-3-4-6-12(11)13(14)9-15/h3-10H,1-2H3

Upstream product

• 75-26-3 isopropyl bromide 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 75-30-9 2-iodo-propane 
• 15052-09-2 2-isopropoxynaphthalene 
• 93-61-8 N-methyl-N-phenylformamide 

Relevant academic research and scientific papers

Application of aromatic nitroethylene compound

The invention provides an application of an aromatic nitroethylene compound. Specifically, the invention provides the application of a compound as shown in a formula (I) and a stereoisomer or pharmaceutically-acceptable salt thereof in preparation of a medicament for regulating the dimer activity of a nuclear receptor RXR or treating neurodegenerative diseases.

Asymmetric Alkynylation of β-Ketoesters and Naphthols Promoted by New Chiral Biphenylic Iodanes

The preparation of new chiral biphenylic λ3-iodane reagents bearing transferable alkynyl ligands is described. These reagents transfer their carbon-based ligands onto β-ketoesters with an enantiomeric excess (ee) up to 68 %, and most remarkably, enable the dearomative alkynylation of naphthols in good to high yields up to 84 % ee.

Remarkable Ability of the Benzylidene Ligand To Control Initiation of Hoveyda–Grubbs Metathesis Catalysts

The structure of the chelating benzylidene ligand offers the unique ability to control the initiation of Hoveyda–Grubbs metathesis catalysts. Apart from steric and electronic effects acting on the step involving opening of the chelate ring, changes related to the following ligand-exchange process may also play a critical role. Our mechanistic model reveals that ligands substituted at the 6-position of the benzylidene ring enter the metathesis cycle in a nonoptimal chelating conformation, and thus the coordination number of the ruthenium center transiently increases to six (associative mechanism). In effect, the synthesis and initiation of the catalysts becomes difficult, and the energy barrier of the ligand-exchange process is controlled by the structure of the coordinating OR group. Moreover, we explain how isomeric naphthalene ligands affect the catalytic performance by an indivisible combination of steric and π-electron delocalization effects.

Synthesis of bulky 1,2-dialkoxy- and 1,2,3-trialkoxy-arenes

A large series of bulky 1,2-dialkoxy- and 1,2,3-trialkoxy-benzenes was efficiently prepared via Williamson etherification. Preparation of their contiguous bromine-containing derivatives was also achieved.

Is the Hoveyda-Grubbs complex a vinylogous fischer-type carbene? Aromaticity-controlled activity of ruthenium metathesis catalysts

Three naphthalene-based analogues (4a-c) of the Hoveyda-Grubbs metathesis catalyst exhibited immense differences in reactivity. Systematic structural and spectroscopic studies revealed that the ruthenafurane ring present in all 2-isopropoxyarylidene chelates possesses some aromatic character, which inhibits catalyst activity. This aromatic stabilization within the chelate ring may be controlled by variation of the polycyclic core topology as was demonstrated for tetraline and phenanthrene derivatives (4d,e). General conclusions about a new mode of ligand-structure tuning in catalytic systems are presented.

NOVEL CERCOSPORAMIDE DERIVATIVE

The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes. A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R1 represents a hydrogen atom or a C1-C6 alkyl group, R2 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 halogenated alkyl group, R3 represents a hydrogen atom or a C1-C6 alkyl group, R4 represents a C6-C10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a C2-C6 alkenyloxy group, a C2-C6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.

4,4'-Binaphthylidene-1,1'-diones - Colour and Structure

Synthesis and properties of various 4,4'-binaphthylidene-1,1'-diones are described.The UV spectra of the deep red to purple diones may be calculated on the base of substituent increments.The experimental values of the analyzed substituents can be reproduced using PPP calculations with satisfying accuracy, which makes it possible to predict also absorption maxima of hitherto unknown 4,4'-binaphthylidene-1,1'-diones.Keywords: 4,4'-Binaphthylidene-1,1'-diones, Phenol Oxidation