88511-25-5

Usage

Uses

Used in Organic Synthesis:
6-IODO-PYRIDIN-2-YLAMINE is used as a key intermediate for the synthesis of a variety of organic compounds due to its reactivity and the ability to undergo multiple types of chemical reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-IODO-PYRIDIN-2-YLAMINE is utilized as a building block for the development of new pharmaceuticals, leveraging its structural features to create novel drug candidates with potential therapeutic applications.
Used in Agrochemical Development:
6-IODO-PYRIDIN-2-YLAMINE also finds use in the agrochemical sector, where it serves as a precursor in the synthesis of compounds with pesticidal or herbicidal properties, contributing to the development of more effective crop protection agents.
Used in Materials Science:
Furthermore, 6-IODO-PYRIDIN-2-YLAMINE has potential applications in materials science, where its unique chemical properties may be harnessed to create new materials with specific characteristics for various industrial uses.
Used as a Precursor in Synthesis:
6-IODO-PYRIDIN-2-YLAMINE is studied for its potential use as a precursor in the synthesis of a range of organic compounds, highlighting its importance in the discovery and creation of new chemical entities.

InChI:InChI=1/C5H5IN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)

Upstream product

• 19798-81-3 2-Amino-6-bromopyridine 

Downstream Products

• 426825-75-4 6-iodoimidazo[1,2-a]pyridine 
• 328062-45-9 6-phenylimidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

Preparation method of 2-amino substituted six-membered nitrogen-containing heterocycle complex

The invention discloses a preparation method of a 2-amino substituted six-membered nitrogen-containing heterocycle complex. The preparation method comprises the following steps: mix 2-fluorine substituted six-membered nitrogen-containing heterocycle complex and amidine hydrochloride salt compound, and then react under the action of a alkaline substance to obtain a 2-amino substituted six-memberednitrogen-containing heterocycle complex. Preferably, the 2-amino substituted six-membered nitrogen-containing heterocycle complex is a 2-amino pyridine compound, a 2-aminopyrimidine compound or a 2-aminopyrazine compound. Compared with the prior art, the method has the advantages of simple synthesis conditions, less reaction steps, mild reaction conditions, low cost of the catalyst used, less waste discharge and good functional group tolerance.

Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of a high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents can also complete the reaction via these reaction conditions and yield the target products.

Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists

Because of their large spectrum of applications, poly-functionalized pyridines remain an attractive challenge in modern organic chemistry. We describe the poly-functionalization of halopyridines through a series of sequential and regioselective palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig reactions). This strategy was applied to the synthesis of several analogs of single non-peptidic known GPR54 antagonists. The Royal Society of Chemistry 2013.

PYRIMIDINES WITH TIE2 (TEK) ACTIVITY

The invention relates to a compound of the Formula (I). or salt thereof wherein R1, R2, R3, R4, R5, R6, A, B, L, n and m are as defined in the description. The invention also relates to pharmaceutical compositions of said compounds, the use of said compounds as medicaments and in the production of an anti-angiogenic effect in a warm-blooded animal. The invention also relates to processes for the preparation of said compounds.