885123-01-3Relevant articles and documents
One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines
Ilyn, Alexey P.,Loseva, Marina V.,Vvedensky, Vladimir Y.,Putsykina, Elena B.,Tkachenko, Sergey E.,Kravchenko, Dmitri V.,Khvat, Alexandr V.,Krasavin, Mikhail Y.,Ivachtchenko, Alexandre V.
, p. 2811 - 2819 (2006)
We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.
