88523-20-0

Basic information

• Product Name: Octanamide, N-[5-[[bis(phenylmethyl)amino]methyl]-4,7-dihydro-4-oxo-1H-pyrrolo[2,3 -d]pyrimidin-2-yl]-
• CAS NO: 88523-20-0
• Molecular Formula: C29H35N5O2
• Molecular Weight: 485.629
• Mol File: 88523-20-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Octanamide, N-[5-[[bis(phenylmethyl)amino]methyl]-4,7-dihydro-4-oxo-1H-pyrrolo[2,3 -d]pyrimidin-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Octanamide, N-[5-[[bis(phenylmethyl)amino]methyl]-4,7-dihydro-4-oxo-1H-pyrrolo[2,3 -d]pyrimidin-2-yl]-(88523-20-0)
• EPA Substance Registry System: Octanamide, N-[5-[[bis(phenylmethyl)amino]methyl]-4,7-dihydro-4-oxo-1H-pyrrolo[2,3 -d]pyrimidin-2-yl]-(88523-20-0)

Safety Data

• Hazardous Substances Data: 88523-20-0(Hazardous Substances Data)

Upstream product

• 111-64-8 n-octanoic acid chloride 
• 7355-55-7 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 50-00-0 formaldehyd 
• 88522-96-7 N-(4-oxo-4,7-dihydro-3H-pyrrolo [2,3-d]pyrimidin-2-yl)octanamide 
• 103-49-1 dibenzylamine 

Downstream Products

• 72496-59-4 queuine 
• 848694-52-0 octanoic acid {4-chloro-5-[(dibenzylamino)-methyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-amide 
• 1025023-30-6 C₂₁H₂₇N₅O₂ 
• 87233-89-4 2-Amino-5-(benzylamino-methyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 118527-66-5 2-Amino-5-phenylaminomethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 

Relevant articles and documents

Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study

Two new series of 5-subtituted and 5,6-disubstituted pyrrolo[2,3-d]pyrimidine octamides (4a–o and 6a–g) and their corresponding free amines 5a–m and 7a–g have been synthesized and biologically evaluated for their antiproliferative activity against three h

SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE DISEASES

The present invention describes compounds of formula (I) (I) Wherein: R1 is selected from H and CH3 R2 is selected from H, C4H9 alkyl, C6H13 alkyl and C3H6-

Synthesis of Queuine, the Base of Naturally Occuring Hypermodified Nucleoside (Queuosine), and Its Analogues

A convenient new method for synthesizing queuine (1) pyrrolopyrimidin-4(3H)-one>, the base of the naturally occuring hypermodified nucleoside, queuosine, present in certain transfer RNAs, and its biosynthetic precursor, 2-amino-5-aminomethylpyrrolopyrimidin-4(3H)-one (2) (Pre Q1 base), was succesfully exploited.This method involved two critical rections: the Mannich reaction using dibenzylamine-formaldehyde of 2-acrylaminopyrrolopyrimidin-4(3H)-one (7), which resulted in the selective introduction of the dibenzylaminomethyl group into the 5-position of (7), and an amine exchange reaction of the 5-dibenzylamino function in the resulting Mannich base (17) with (1S,2R,3S)-2,3-isopropylidenedioxycyclopent-4-enylamine, which yielded the desired queuine (1).Similar reaction of (17) with ammonia gave the biosynthetic precursor of queuine (2) (Pre Q1 base).Thus, a series of queuine analogues with structural variations in their 5-aminomethyl side-chains was synthesized by the amine exchange reaction of (17) with appropriate amines or by acylation of (2) with appropriate acylating agents.