88525-49-9

Upstream product

• 79-30-1 isobutyryl chloride 
• 768-60-5 4-methoxyphenylacetylen 
• 88525-50-2 1-(4-methoxyphenyl)-4-methylpent-1-yn-3-ol 

Downstream Products

• 109292-79-7 (2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid 
• 109292-79-7 (2R,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid 
• 88525-56-8 (2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid ethyl ester 
• 88525-56-8 (2R,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid ethyl ester 
• 88525-57-9 C₂₆H₃₁ClO₆Si 
• 88525-57-9 C₂₆H₃₁ClO₆Si 
• 80902-00-7 (3S,4R)-3-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-4-hydroxy-4-isopropyl-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-dihydro-furan-2-one 
• 80902-00-7 Cyanobacterin 
• 88525-60-4 (3R,4S)-3-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-4-hydroxy-4-isopropyl-6-(4-methoxy-phenyl)-3,4-dihydro-pyran-2-one 
• 88525-60-4 (3S,4S)-3-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-4-hydroxy-4-isopropyl-6-(4-methoxy-phenyl)-3,4-dihydro-pyran-2-one 

Relevant academic research and scientific papers

Asymmetric Enamide–Imine Tautomerism in the Kinetic Resolution of Tertiary Alcohols

An efficient protocol for kinetic resolution of tertiary alcohols has been developed through an unprecedented asymmetric enamide-imine tautomerism process enabled by chiral phosphoric acid catalysis. A broad range of racemic 2-arylsulfonamido tertiary allyl alcohols could be kinetically resolved with excellent kinetic resolution performances (with s-factor up to >200). This method is particularly effective for a series of 1,1-dialkyl substituted allyl alcohols, which produced chiral tertiary alcohols that would be difficult to access via other asymmetric methods. Facile and versatile transformations of the chiral α-hydroxy imine and enamide products, especially the efficient stereodivergent synthesis of all four stereoisomers of β-amino tertiary alcohols using one enantiomer of the catalyst, demonstrated the value of this kinetic resolution method.

SUBSTITUTED PYRAZOLO [1,5-α] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to substituted pyrazolo[l,5-α]pyridines and related methods for their synthesis and use.

Total Synthesis and X-ray Structure Determination of Cyanobacterin

Racemic cyanobacterin has been synthesized and subjected to X-ray diffraction analysis in order to establish unambiguously the structure.