88525-50-2

Upstream product

• 78-84-2 isobutyraldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 558-30-5 2-methyl-1,2-epoxypropane 
• 61926-37-2 1-(iodoethynyl)-4-methoxybenzene 

Downstream Products

• 88525-49-9 1-(4-methoxyphenyl)-4-methylpent-1-yn-3-one 
• 109292-79-7 (2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid 
• 109292-79-7 (2R,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid 
• 80902-00-7 (3S,4R)-3-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-4-hydroxy-4-isopropyl-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-dihydro-furan-2-one 
• 80902-00-7 Cyanobacterin 
• 88525-60-4 (3R,4S)-3-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-4-hydroxy-4-isopropyl-6-(4-methoxy-phenyl)-3,4-dihydro-pyran-2-one 
• 88525-60-4 (3S,4S)-3-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-4-hydroxy-4-isopropyl-6-(4-methoxy-phenyl)-3,4-dihydro-pyran-2-one 
• 88525-56-8 (2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid ethyl ester 
• 88525-56-8 (2R,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid ethyl ester 
• 88525-57-9 C₂₆H₃₁ClO₆Si 
• 88525-57-9 C₂₆H₃₁ClO₆Si 
• 1311378-56-9 (E)-4-(4-methoxyphenyl)-3-(2-methylpropylidene)-2-[(4-trifluoromethyl)phenyl]-2,3-dihydroazete 1-oxide 
• 1311378-42-3 (E)-4-(trifluoromethyl)benzaldehyde O-[1-(4-methoxyphenyl)-4-methylpent-1-yn-3-yl]oxime 
• 1388625-07-7 C₁₃H₁₇NO₂ 

Relevant academic research and scientific papers

Ti-catalyzed regioselective ring-opening alkynylation of epoxides with haloalkynes

Ti-catalyzed ring-opening alkynylation of epoxides with haloalkynes has been achieved, allowing an efficient and regioselective entry to various propargylic alcohols in moderate to good yields. The developed protocol features extremely mild reaction conditions, broad substrate scope, varied functional group compatibility, and chemospecificity in the rearrangements of epoxides to aldehydes.

Formation of β-Oxo- N-vinylimidates via Intermolecular Ester Incorporation in Huisgen Cyclization/Carbene Cascade Reactions

Unusual intermolecular trapping of esters by carbenes generated via a Huisgen cyclization/retroelectrocyclization/dediazotization cascade reaction is presented. β-Oxo-N-vinylimidates could be obtained in one step from propargyl carbonazidates. Mechanistic control experiments suggested reversible dipole formation by ester addition to the carbene, and nitrogen attack to the ester carbonyl was irreversibly followed by stereoselective decarboxylative elimination to give the Z-vinyl imidate. The cross-conjugated enone, imidate, and enamine functional groups in the β-oxo-N-vinylimidates offer novel syntheses of functionalized oxazoles.

Total Synthesis and X-ray Structure Determination of Cyanobacterin

Racemic cyanobacterin has been synthesized and subjected to X-ray diffraction analysis in order to establish unambiguously the structure.