885272-84-4

Basic information

• Product Name: Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenyl-
• Synonyms: Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenyl-;2-phenyl-imidazo[1,2-a]pyridine-3-acetonitrile;2-(2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-YL)ACETONITRILE
• CAS NO: 885272-84-4
• Molecular Formula: C15H11N3
• Molecular Weight: 233.27
• Mol File: 885272-84-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.16
• PKA: 5.47±0.50(Predicted)
• CAS DataBase Reference: Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenyl-(885272-84-4)
• EPA Substance Registry System: Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenyl-(885272-84-4)

Safety Data

• Hazardous Substances Data: 885272-84-4(Hazardous Substances Data)

Usage

Description

Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenylis a chemical compound with the molecular formula C14H9N3. It is a derivative of imidazo[1,2-a]pyridine, featuring a phenyl group attached to the nitrogen atom at position 2. Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenylis of interest to researchers in medicinal chemistry and drug discovery due to its potential biological activity and structural features, which may contribute to the development of new pharmaceutical agents.

Uses

Used in Medicinal Chemistry:
Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenylis used as a chemical intermediate for the synthesis of various pharmaceutical agents. Its unique structure allows for the development of compounds with potential therapeutic applications.
Used in Drug Discovery:
Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenylis utilized in drug discovery as a lead compound for the identification of novel therapeutic agents. Its structural features may contribute to the design of new drugs with improved efficacy and selectivity.
Used in Research:
Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenylis employed in research studies to investigate the biological and pharmacological properties of imidazo[1,2-a]pyridine derivatives. This helps in understanding their potential use in the development of new pharmaceutical agents and contributes to the advancement of medicinal chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenylis used as a key building block for the synthesis of drug candidates. Its unique structural features enable the development of innovative therapeutic agents with improved pharmacological properties.
Used in Chemical Synthesis:
Imidazo[1,2-a]pyridine-3-acetonitrile, 2-phenylis utilized in chemical synthesis for the preparation of various imidazo[1,2-a]pyridine derivatives. These derivatives may exhibit diverse biological activities and can be further optimized for specific therapeutic applications.

Upstream product

• 504-29-0 2-aminopyridine 
• 70-11-1 α-bromoacetophenone 
• 590-17-0 cyanomethyl bromide 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 13138-21-1 diazoacetonitrile 
• 75-05-8 acetonitrile 
• 59463-54-6 S-cyanomethyl O-ethyl carbonodithioate 
• 151-50-8 potassium cyanide 
• 365213-40-7 N,N-dimethyl-1-(2-phenylimidazo[1,2-a]pyridin-3-yl)methanamine 

Relevant articles and documents

Synthesis of C3-Cyanomethylated Imidazo[1,2- a ]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-Free Conditions

An efficient synthesis of C3-cyanomethylated imidazo[1,2-α]pyridines via ultrasound-promoted three-component reaction under catalyst-free, oxidant-free, and mild conditions has been developed. A series of C3-cyanomethylated imidazo[1,2-α]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility. This strategy cloud also be applied to the synthesis of zolpidem and alpidem in short steps.

Synthesis method of naphtho[1', 2': 4, 5]imidazo[1, 2-a]pyridine-5, 6-diketone compound

The invention discloses a synthetic method of a naphtho[1', 2': 4, 5]imidazo[1, 2-a]pyridine-5, 6-diketone compound, which belongs to the technical field of organic chemistry. The synthesis method comprises the following steps: taking 2-aryl imidazo[1, 2-a] pyridine compound and diazonium acetonitrile as raw materials; synthesizing a 3-cyanomethylated imidazo[1, 2-a]pyridine compound 3 in the presence of a catalyst, reacting the compound 3 with an alcohol under the action of an acid to obtain an imidazo [1, 2-a] pyridine-3-acetate compound 4, and finally heating PPA to condense into a ring andsimutanously forms naphtho[1', 2': 4, 5]imidazo[1, 2-a]pyridine-5,6-dione 5. The whole process of the method is carried out in the air, the used catalysts are common catalysts, the method is low in cost and environmentally friendly, the raw materials are easy to obtain, and a new synthesis path is provided for the compounds.

FeCl3-catalyzed C-3 functionalization of imidazo[1,2-a]pyridines with diazoacetonitrile under oxidant- and ligand-free conditions

A facile synthesis of 2-(imidazo[1,2-a]pyridin-3-yl)acetonitriles via FeCl3-catalyzed site-selective C(sp2)-H alkylation of imidazo[1,2-a]pyridines with diazoacetonitrile is presented. This new method features with an environmentally benign catalyst, easily obtainable substrates, and oxidant- and ligand-free reaction conditions. Moreover, the importance of the products thus obtained is showcased by their ready transformation into some synthetically and pharmaceutically interesting products with good efficiency.