885273-64-3 Usage
General Description
3-(2-Bromo-phenyl)-isoxazole-5-carboxylic acid ethyl ester is a chemical compound with the molecular formula C12H9BrN2O3. It is an organic compound that belongs to the class of isoxazole derivatives, which are known for their diverse biological activities. This specific compound is an ethyl ester, indicating that it contains an ethyl group attached to the carboxylic acid functional group. The presence of the 2-bromo-phenyl group suggests potential reactivity and possible use in pharmaceutical or agrochemical applications. The compound's structural features also indicate the potential for use as a building block in organic synthesis or as a precursor in the development of new pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 885273-64-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,7 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 885273-64:
(8*8)+(7*8)+(6*5)+(5*2)+(4*7)+(3*3)+(2*6)+(1*4)=213
213 % 10 = 3
So 885273-64-3 is a valid CAS Registry Number.
885273-64-3Relevant articles and documents
Alkyl Nitrites: Novel Reagents for One-Pot Synthesis of 3,5-Disubstituted Isoxazoles from Aldoximes and Alkynes
Kadam, Kishorkumar S.,Gandhi, Thirumanavelan,Gupte, Amol,Gangopadhyay,Sharma, Rajiv
, p. 3996 - 4008 (2016)
An efficient, one-pot approach has been described for the synthesis of 3,5-disubstituted isoxazoles from substituted aldoximes (mixture of E and Z) and alkynes, using alkyl nitrites under conventional heating conditions. The key nitrile oxide intermediates that are required for the synthesis of isoxazoles are formed by treatment of substituted aldoxime with either tert-butyl nitrite or isoamyl nitrite. The generated nitrile oxides underwent in situ [3+2] dipolar cycloaddition to the substituted alkynes to give 3,5-disubstituted isoxazoles regioselectively in high to excellent yields. The developed synthetic methodology was applied for the synthesis of a previously reported potent hDGAT1 inhibitor.
