885273-76-7

Basic information

• Product Name: [2-(4-METHOXY-PHENYL)-OXAZOL-4-YL]-METHANOL
• Synonyms: [2-(4-METHOXY-PHENYL)-OXAZOL-4-YL]-METHANOL
• CAS NO: 885273-76-7
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• Mol File: 885273-76-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [2-(4-METHOXY-PHENYL)-OXAZOL-4-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-METHOXY-PHENYL)-OXAZOL-4-YL]-METHANOL(885273-76-7)
• EPA Substance Registry System: [2-(4-METHOXY-PHENYL)-OXAZOL-4-YL]-METHANOL(885273-76-7)

Safety Data

• Hazardous Substances Data: 885273-76-7(Hazardous Substances Data)

Usage

General Description

[2-(4-Methoxy-phenyl)-oxazol-4-yl]-methanol, also known as 4-Methoxyphenyl-2-oxazol-4-yl-methanol, is a chemical compound with the molecular formula C11H11NO3. It is an oxazole derivative that contains a methanol group and a methoxyphenyl group. [2-(4-METHOXY-PHENYL)-OXAZOL-4-YL]-METHANOL is a white to off-white solid and is commonly used in organic synthesis and pharmaceutical research. It has properties that make it suitable for use as a building block in the development of new pharmaceuticals, agrochemicals, and other specialty chemical products. The chemical structure of [2-(4-Methoxy-phenyl)-oxazol-4-yl]-methanol makes it a versatile and valuable compound for various applications in the chemical industry.

Upstream product

• 154405-98-8 methyl 2-(4-methoxyphenyl)-1,3-oxazole-4-carboxylate 
• 6704-31-0 oxetan-3-one 
• 3424-93-9 4-methoxyphenylacetamide 

Downstream Products

• 167155-56-8 4-(chloromethyl)-2-(4-methoxyphenyl)oxazole 

Relevant articles and documents

Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTB

A high-throughput screening effort on 45,000 compounds resulted in the discovery of a disubstituted oxazole as a new structural class inhibitor of Mycobacterium tuberculosis (Mtb). In order to improve the activity and investigate the SAR of this scaffold, a series of disubstituted azole analogues have been designed and synthesized. The newly synthesized compounds 1a-y were evaluated for their in vitro anti-TB activity versus replicating, multi- and extensive drug resistant Mtb strains. All the compounds, except 1o, 1p and 1q, showed potent anti-TB activity with MIC of 1-64 mg/L. The test of broad spectrum panel revealed that this series are specific to Mtb. The cytotoxicity assessment indicated that the compounds were not cytotoxic against HEK 293 cells. The compounds could have a novel mechanism to anti-Mtb as they can inhibit drug sensitive and drug resistant Mtb.