885277-01-0

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-CHLORO-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE is used as a precursor in the production of herbicides, pesticides, and insecticides, leveraging its chemical properties to enhance the effectiveness of these agricultural chemicals in controlling weeds, pests, and insects.
Safety Considerations:
Due to its classification as a hazardous substance, 2-CHLORO-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE should be handled with caution to prevent skin and eye irritation, ensuring proper safety measures are in place during its use in both pharmaceutical and agrochemical applications.

Upstream product

• 34941-91-8 2-chloro-4-fluoropyridine 
• 75-89-8 2,2,2-trifluoroethanol 
• 23056-36-2 2-chloro-4-nitropyridine 

Relevant academic research and scientific papers

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and in vivo exposures are potentially limited due to poor physicochemical properties. We initiated a GLS-1 inhibitor discovery program focused on optimizing physicochemical and pharmacokinetic properties, and have developed a new selective inhibitor, compound 27 (IPN60090), which is currently in phase 1 clinical trials. Compound 27 attains high oral exposures in preclinical species, with strong in vivo target engagement, and should robustly inhibit glutaminase in humans.

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.