885277-08-7

Basic information

• Product Name: 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE
• Synonyms: 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE;5-Chloro-2-Pyridinesulfonylchloride
• CAS NO: 885277-08-7
• Molecular Formula: C₅H₃Cl₂NO₂S
• Molecular Weight: 212.05
• Mol File: 885277-08-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 288.8 °C at 760 mmHg
• Flash Point: 128.5 °C
• Appearance: /
• Density: 1.615 g/cm³
• Vapor Pressure: 0.00396mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -7.42±0.29(Predicted)
• CAS DataBase Reference: 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE(885277-08-7)
• EPA Substance Registry System: 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE(885277-08-7)

Safety Data

• Hazardous Substances Data: 885277-08-7(Hazardous Substances Data)

Usage

General Description

5-Chloro-pyridine-2-sulfonyl chloride is a chemical compound with the molecular formula C5H3Cl2NO2S. It is a yellow solid that is primarily used in the synthesis of pharmaceuticals and agrochemicals. 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE is a versatile building block in organic synthesis, particularly in the preparation of heterocyclic compounds. It is known for its strong reactivity with nucleophiles and is often used as a reagent in the production of various chemicals. 5-Chloro-pyridine-2-sulfonyl chloride is also a valuable intermediate in the manufacturing of dyes and pigments, as well as in the production of specialty chemicals. However, it is important to handle this compound with caution due to its corrosive and toxic nature.

InChI:InChI=1/C5H3Cl2NO2S/c6-4-1-2-5(8-3-4)11(7,9)10/h1-3H

Upstream product

• 40771-41-3 2-mercapto-5-chloro-pyridine 
• 1480-65-5 2-fluoro-5-chloropyridine 

Relevant articles and documents

Desulfonative Suzuki–Miyaura Coupling of Sulfonyl Fluorides

Sulfonyl fluorides have emerged as powerful “click” electrophiles to access sulfonylated derivatives. Yet, they are relatively inert towards C?C bond forming transformations, notably under transition-metal catalysis. Here, we describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki–Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogues of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S?Nu and C?C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C?S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE ABSTRACT OF THE DISCLOSURE The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: {INSERT STRUCTURE HERE} I wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.