885277-08-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-pyridine-2-sulfonyl chloride is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of heterocyclic compounds, which are essential in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE is utilized as a precursor in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Dye and Pigment Industry:
5-Chloro-pyridine-2-sulfonyl chloride is employed as an intermediate in the manufacturing of dyes and pigments, playing a crucial role in the coloration processes of various materials.
Used in Specialty Chemicals Production:
5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE is used as a reagent in the production of specialty chemicals, where its strong reactivity with nucleophiles is leveraged to create unique chemical entities for specific applications.

InChI:InChI=1/C5H3Cl2NO2S/c6-4-1-2-5(8-3-4)11(7,9)10/h1-3H

Upstream product

• 40771-41-3 2-mercapto-5-chloro-pyridine 
• 1480-65-5 2-fluoro-5-chloropyridine 

Relevant academic research and scientific papers

Desulfonative Suzuki–Miyaura Coupling of Sulfonyl Fluorides

Sulfonyl fluorides have emerged as powerful “click” electrophiles to access sulfonylated derivatives. Yet, they are relatively inert towards C?C bond forming transformations, notably under transition-metal catalysis. Here, we describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki–Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogues of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S?Nu and C?C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C?S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.

SULFONYL PYRIDYL TRP INHIBITORS

The invention is concerned with the compounds of formula I: (I) and pharmaceutically acceptable salts thereof where R1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, t

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE ABSTRACT OF THE DISCLOSURE The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: {INSERT STRUCTURE HERE} I wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.