885280-09-1

Basic information

• Product Name: C-[2-(2-CHLORO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE
• Synonyms: C-[2-(2-CHLORO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE;2-(2-chlorophenyl)-4-Thiazolemethanamine;(2-(2-Chlorophenyl)thiazol-4-yl)methanamine
• CAS NO: 885280-09-1
• Molecular Formula: C10H9ClN2S
• Molecular Weight: 224.71
• Mol File: 885280-09-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: C-[2-(2-CHLORO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-[2-(2-CHLORO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE(885280-09-1)
• EPA Substance Registry System: C-[2-(2-CHLORO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE(885280-09-1)

Safety Data

• Hazardous Substances Data: 885280-09-1(Hazardous Substances Data)

Upstream product

• 609-66-5 2-chlorobenzamide 
• 118-91-2 ortho-chlorobenzoic acid 
• 588676-51-1 4-chloromethyl-2-(2-chloro-phenyl)-thiazole 
• 15717-17-6 2-chlorothiobenzamide 

Relevant articles and documents

Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring

Pyrazolecarboxamide fungicides are one of the most important classes of agricultural fungicides, which belong to succinodehydrogenase inhibitors (SDHIS). To discover new pyrazolecarboxamide analogues with broad spectrum and high activity, a class of new compounds of pyrazole carboxamide derivatives containing thiazole or oxazole ring were designed by scaffold hopping and bioisosterism, and 36 pyrazole carboxamide derivatives with antifungal activity were synthesized. Those compounds were evaluated against five phytopathogenic fungi, Gibberella zeae, Phytophythora capsici, Sclerotonia sclerotiorum, Erysiphe graminis and Puccinia sorghi. The results indicated that most of the compounds displayed good fungicidal activities, especially against E. graminis. Theoretical calculations were carried out at the B3LYP/6-31G (d, p) level and the full geometry optimization was carried out using the 6-31G (d, p) basis set, and the frontier orbital energy, atomic net charges, molecular docking were discussed, and the structure-activity relationships were also studied.

Synthesis and insecticidal activities of novel 1H-pyrazole-5-carboxylic acid derivatives

Fourteen 1H-pyrazole-5-carboxylic acid derivatives containing oxazole and thiazole rings were synthesized and characterized by 1H NMR, mass spectrometry and elemental analysis. Most target compounds were obtained in overall yields in the range of 30-50%. The insecticidal activities of these new compounds against Aphis fabae were evaluated. The bioassays' results indicate that some of these compounds exhibit good activities, especially compound 7h which shows 85.7% mortality against A. fabae at a concentration of 12.5 mg/L. This activity is comparable to that of the commercial insecticide imidacloprid.