885280-30-8

Basic information

• Product Name: 2'-AMINO-BIPHENYL-4-CARBALDEHYDE
• Synonyms: 2'-AMINO-BIPHENYL-4-CARBALDEHYDE;2'-AMino-[1,1'-biphenyl]-4-carbaldehyde
• CAS NO: 885280-30-8
• Molecular Formula: C13H11NO
• Molecular Weight: 197.23
• Mol File: 885280-30-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-AMINO-BIPHENYL-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-AMINO-BIPHENYL-4-CARBALDEHYDE(885280-30-8)
• EPA Substance Registry System: 2'-AMINO-BIPHENYL-4-CARBALDEHYDE(885280-30-8)

Safety Data

• Hazardous Substances Data: 885280-30-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2'-Amino-biphenyl-4-carbaldehyde is used as a key intermediate in the synthesis of pharmaceuticals for its potential application in the development of new drugs.
Used in Dye and Pigment Industry:
2'-Amino-biphenyl-4-carbaldehyde is used as a key intermediate in the production of dyes and pigments due to its chemical properties.
It is important to handle and dispose of 2'-Amino-biphenyl-4-carbaldehyde properly to prevent harm to human health and the environment.

Upstream product

• 169188-17-4 2'-nitro-1,1'-biphenyl-4-carboxaldehyde 
• 615-43-0 2-iodophenylamine 
• 87199-17-5 4-formylphenylboronic acid, 

Relevant articles and documents

α-Bromoacrylic Acids as C1 Insertion Units for Palladium-Catalyzed Decarboxylative Synthesis of Diverse Dibenzofulvenes

Herein α-bromoacrylic acids have been employed as C1 insertion units to achieve the palladium-catalyzed [4 + 1] annulation of 2-iodobiphenyls, which provides an efficient platform for the construction of diverse dibenzofulvenes. This protocol enables the formation of double C(aryl)-C(vinyl) bonds via a C(vinyl)-Br bond cleavage and decarboxylation. It is particularly noteworthy that the method features a broad substrate scope, and various interesting frameworks, such as bridged ring, fused (hetero)aromatic ring, and divinylbenzene, can be successfully incorporated into the products.

Indium powder as the reducing agent in the synthesis of 2-amino-1,1′-biphenyls

An improved and simplified In-based protocol for the reduction of 2-nitro-1,1′-biphenyls to the corresponding 2-amino-1,1′-biphenyls is disclosed. The method utilizes only a stoichiometric quantity of indium powder as the reducing reagent along with a stoichiometric quantity of ammonium chloride. The work-up is very simple, it requires only a simple filtration of the post-reaction mixture whereupon the reaction medium is removed under reduced pressure. The method was also proven to operate with a variety of functional groups to provide high to excellent yields of the target 2-amino-1,1′-biphenyls. A proposal for a reaction mechanism is also provided.