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885280-83-1

5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE is a hydrochloride salt form of an amine derivative featuring a benzofuran structure with a fluorine substituent. This chemical compound holds potential pharmaceutical applications due to its possible neuroprotective and antitumor properties, positioning it as a candidate for the development of new medications for various medical conditions.

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  • 885280-83-1 Structure

  • Basic information

    1. Product Name: 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE
    2. Synonyms: 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE
    3. CAS NO:885280-83-1
    4. Molecular Formula: C8H8FNO
    5. Molecular Weight: 189.6145632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 885280-83-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE(885280-83-1)
    11. EPA Substance Registry System: 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE(885280-83-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 885280-83-1(Hazardous Substances Data)

885280-83-1 Usage

Uses

Used in Pharmaceutical Industry:
5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE is used as a potential therapeutic agent for the treatment of neurological disorders due to its neuroprotective properties. It may help in safeguarding neurons from damage or degeneration, thereby offering a new avenue for managing such conditions.
Used in Oncology:
In the field of oncology, 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE is used as a potential antitumor agent. Its capacity to inhibit tumor growth and progression makes it a promising candidate for cancer treatment, potentially leading to the development of novel cancer therapies.
Further research is essential to fully elucidate the pharmacological properties and explore the therapeutic potential of 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE in these applications.

Check Digit Verification of cas no

The CAS Registry Mumber 885280-83-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,8 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 885280-83:
(8*8)+(7*8)+(6*5)+(5*2)+(4*8)+(3*0)+(2*8)+(1*3)=211
211 % 10 = 1
So 885280-83-1 is a valid CAS Registry Number.

885280-83-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-fluoro-2,3-dihydro-1-benzofuran-3-amine

1.2 Other means of identification

Product number -
Other names 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:885280-83-1 SDS

885280-83-1Downstream Products

885280-83-1Relevant articles and documents

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators

Pettersson, Martin,Johnson, Douglas S.,Subramanyam, Chakrapani,Bales, Kelly R.,Am Ende, Christopher W.,Fish, Benjamin A.,Green, Michael E.,Kauffman, Gregory W.,Lira, Ricardo,Mullins, Patrick B.,Navaratnam, Thayalan,Sakya, Subas M.,Stiff, Cory M.,Tran, Tuan P.,Vetelino, Beth C.,Xie, Longfei,Zhang, Liming,Pustilnik, Leslie R.,Wood, Kathleen M.,O'Donnell, Christopher J.

, p. 2906 - 2911 (2012/06/04)

We report the discovery and optimization of a novel series of dihydrobenzofuran amides as γ-secretase modulators (GSMs). Strategies for aligning in vitro potency with drug-like physicochemical properties and good microsomal stability while avoiding P-gp mediated efflux are discussed. Lead compounds such as 35 and 43 have moderate to good in vitro potency and excellent selectivity against Notch. Good oral bioavailability was achieved as well as robust brain Aβ42 lowering activity at 100 mg/kg po dose.

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