885323-66-0

Basic information

• Product Name: (E,3RS,5S)-3-(8'-iodooct-7'-enyl)-5-methyl-3-(phenylsulfanyl)tetrahydrofuran-2-one
• Synonyms: (E,3RS,5S)-3-(8'-iodooct-7'-enyl)-5-methyl-3-(phenylsulfanyl)tetrahydrofuran-2-one
• CAS NO: 885323-66-0
• Molecular Weight: 444.377
• Mol File: 885323-66-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E,3RS,5S)-3-(8'-iodooct-7'-enyl)-5-methyl-3-(phenylsulfanyl)tetrahydrofuran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E,3RS,5S)-3-(8'-iodooct-7'-enyl)-5-methyl-3-(phenylsulfanyl)tetrahydrofuran-2-one(885323-66-0)
• EPA Substance Registry System: (E,3RS,5S)-3-(8'-iodooct-7'-enyl)-5-methyl-3-(phenylsulfanyl)tetrahydrofuran-2-one(885323-66-0)

Safety Data

• Hazardous Substances Data: 885323-66-0(Hazardous Substances Data)

Upstream product

• 65785-44-6 6-iodohexanol, tetrahydropyranyl ether 
• 16695-31-1 1-(2-Tetrahydropyranyloxy)-7-octyne 
• 629-11-8 1,6-hexanediol 
• 158664-38-1 (E)-8-iodooct-7-en-1-ol 
• 63294-76-8 6-<(tetrahydro-2H-pyran-2-yl)oxy>hexyl toluene-4-sulfonate 
• 28659-22-5 6-(tetrahydro-2H-pyranyloxy)hexan-1-ol 
• 1027299-13-3 Toluene-4-sulfonic acid (E)-8-iodo-oct-7-enyl ester 
• 184435-75-4 (5S)-5-methyl-3-phenylsulfanyl-4,5-dihydrofuran-2(3H)-one 
• 158664-40-5 (E)-1,8-diiodooct-1-ene 

Relevant articles and documents

Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I

A convergent stereoselective synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin and squamostolide was accomplished via a Pd-catalyzed cross-coupling reaction. The inhibitory activity of these compounds was examined with bovine heart mitochondrial NADH-ubiquinone oxidoreductase. These compounds showed a remarkably weak inhibitory activity compared to ordinary acetogenins such as bullatacin. Our results indicate that to maintain potent inhibitory effect, the hydroxylated lactone cannot substitute for the hydroxylated mono- or bis-THF rings with a long alkyl chain that can be seen in ordinary acetogenins.