88534-50-3

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-5-PHENYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER is used as a key intermediate in the synthesis of various drugs and organic compounds, contributing to the development of new pharmaceutical agents.
Used in Medicinal Chemistry:
3-AMINO-5-PHENYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER is used as a building block for the development of new pharmaceutical agents, leveraging its unique chemical structure and biological activities to create novel molecules with therapeutic potential.
Used in Drug Discovery and Development:
3-AMINO-5-PHENYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER is used as a starting material for the preparation of novel molecules with therapeutic potential, facilitating the discovery and development of new drugs with improved efficacy and safety profiles.

Upstream product

• 3755-96-2 (2Z)-3-bromo-3-phenylprop-2-enenitrile 
• 623-51-8 ethyl 2-sulfanylacetate 
• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 
• 78583-84-3 3-chloro-3-phenylprop-2-enenitrile 
• 78583-84-3 (Z)-3-chloro-3-phenyl-2-propenenitrile 
• 62979-66-2 α-Chlor-zimtsaeure-nitril 

Downstream Products

• 37572-02-4 2-ethoxy-6-phenyl-2-thioxo-1,2-dihydro-2λ⁵-thieno[3,2-d][1,3,2]thiazaphosphinine-4-thione 
• 99972-47-1 3-amino-5-phenyl-2-thiophenecarboxylic acid 
• 1234799-80-4 2-amino-6-phenylthieno[3,2-d]pyrimidin-4(3H)-one 
• 1574650-56-8 C₁₃H₁₁N₃O₂S 
• 1574650-73-9 methyl 5-oxo-7-phenyl-4,5-dihydrothieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine-3-carbimidate 

Relevant academic research and scientific papers

New Convenient Strategy for Annulation of Pyrimidines to Thiophenes or Furans via the One-pot Multistep Cascade Reaction of 1 H -Tetrazoles with Aliphatic Amines

A versatile, convenient, efficient and high-yield synthetic method for 2-R3,R4-amino-5-R1-6-R2-thieno[2,3-d]pyrimidin-4(3H)-ones, 2-R3,R4-amino-5-R1-6-R2-thieno[3,2-d]pyrimidin-4(3H)-ones, and benzofuro[3,2-d]pyrimidin-4(3H)-ones preparation has been developed. The reaction proceeded without using solvents and included several steps. A variety of thieno[2,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives with substituents of different nature were obtained in high yields from substituted alkyl 2-(1H-tetrazol-1-yl)thiophene-3-carboxylates, 3-(1H-tetrazol-1-yl)thiophene-2-carboxylates, and 3-(1H-tetrazol-1-yl)benzofuran-2-carboxylate after their treatment with aliphatic amines.

Facile and efficient one-pot procedure for thieno[2,3-e][1,2,3]triazolo[1, 5-a]pyrimidines preparation

Base-catalyzed cycloaddition reactions of heterocyclic azides with activated nitriles were studied. Convenient, efficient, and high-yield synthetic method for thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines preparation from available starting reagents without complicated protocols was elaborated. Such an approach allows creation of broad combinatorial libraries for drug discovery. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Gallium (iii)-catalysed bromocyanation of alkynes: Regio- and stereoselective synthesis of β-bromo-α,β-unsaturated nitriles

Treatment of arylacetylenes and cyanogen bromide in ClCH2CH 2Cl with a catalytic amount of GaCl3 afforded (Z)-β-bromoacrylonitriles with high regio- and stereoselectivity.

Synthesis of thiazolidinones and azetidinones from hydrazino thieno [3,2-d]pyrimidines as potential antimicrobial agents

4-Hydrazino-6-phenylthieno [3,2-d] pyrimidine 5 on treatment with aromatic aldehydes yield 4-substituted-benzalhydrazino-6-phenylthieno [3,2-d] pyrimidine 6a-k, which on cyclisation with thioglycolic and thiolactic acid afford corresponding 2-aryl-3-N-(6′

Synthesis of some 2-substituted-6-phenyl- and 7-phenyl-thienopyrimidin-4(3H)-ones

The title compounds, 7a-j and 8a-c, have been prepared through cyclocondensation of the corresponding thiophene o-aminoesters (5a and 5b) with a variety of nitriles in the presence of dry hydrogen chloride gas.