885519-33-5

Usage

Uses

Used in Pharmaceutical Industry:
4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER is used as a chemical intermediate for the synthesis of pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents. Its ability to modify the biological activity of molecules makes it a valuable asset in medicinal chemistry.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER is utilized as a research tool to explore and understand the structure-activity relationships of various molecules. This helps in the design and optimization of more effective and safer pharmaceutical agents.
Used in Drug Development:
4-IODO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER plays a role in drug development by serving as a building block for the creation of novel drug candidates. Its properties allow for the fine-tuning of drug candidates to enhance their efficacy, selectivity, and safety profiles.

Upstream product

• 72922-60-2 methyl 3-amino-4-methyl-5-nitrobenzoate 
• 21323-99-9 methyl 3-iodo-4-methyl-5-nitrobenzoate 
• 21324-00-5 methyl 3-amino-5-iodo-4-methylbenzoate 

Relevant academic research and scientific papers

NOVEL RENIN INHIBITOR

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein R1 is a cycloalkyl group or an alkyl, R22 is an optionally substituted aryl and the like, R is a lower alkyl group, R3, R4, R5 and R6 are the same or different, and are a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof.

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I]: wherein R1 is a cycloalkyl group and the like, R22 is an optionally substituted aryl and the like, R is a lower alkyl and the like, T is a carbonyl group, Z is -O- and the like, and R3 to R6 are the same or different and a hydrogen atom and the like; or a pharmaceutically acceptable salt, that is useful as a renin inhibitor.

INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.