885677-77-0Relevant academic research and scientific papers
Trans -1,2-Diaminocyclohexane-based sulfonamides as effective hydrogen-bonding organocatalysts for asymmetric Michael-hemiacetalization reaction
Dajek, Maciej,Kowalczyk, Rafa?,Boratyński, Przemys?aw J.
, p. 4358 - 4363 (2018)
An easily attainable bifunctional monosulfonamide derivative of DACH was an effective catalyst for Michael addition-hemiacetalization reactions, providing products with ees exceeding 99% under optimized conditions. High enantioselectivities were achieved with just 0.2% mol catalyst loading. The sulfonamide outperformed analogous thiourea and squaramide-based organocatalysts.
Chemoenzymatic syntheses of novel ligands derived from trans-cyclohexane-1, 2-diamine: Application in the enantioselective addition of diethylzinc to aromatic aldehydes
Gonzalez-Sabin, Javier,Gotor, Vicente,Rebolledo, Francisca
, p. 449 - 454 (2007/10/03)
Enantiopure (1R,2R)-cyclohexane-1,2-diamine derivatives, easily prepared from the corresponding (±)-trans-2-dialkylaminocyclohexanols through a chemoenzymatic route, have been employed as ligands in the enantioselective addition of diethylzinc to aromatic aldehydes. Of all the ligands tested, C 2-symmetric bisaminoamides derived from pyridine-2,6-dicarboxylic acid proved to be the most efficient.
