88569-66-8

Usage

Uses

Used in Pharmaceutical Industry:
N-Isopropylpiperazine dihydrochloride is used as a key intermediate in the synthesis of various drugs, particularly for the development of antiviral, antimicrobial, and antifungal medications. Its role in drug production is crucial due to its ability to contribute to the creation of effective treatments for a range of infections and diseases.
Used in Organic Synthesis:
In the field of organic synthesis, N-Isopropylpiperazine dihydrochloride is utilized as a reagent. This application takes advantage of its chemical properties to facilitate reactions and synthesize a variety of organic compounds for different purposes, including but not limited to research, industrial processes, and the development of new materials.

Upstream product

• 13961-36-9 1-allylpiperazine 
• 741287-46-7 tert-butyl 4-isopropylpiperazine-1-carboxylate 

Downstream Products

• 941320-31-6 1-[4-(4-isopropyl-piperazine-1-carbonyl)-phenyl]-ethanone 
• 552885-52-6 ethyl 4-[2-(4-fluorophenyl)-2-(4-isopropylpiperazin-1-yl)ethyl]piperazine-1-carboxylate 
• 914606-84-1 1-(5-bromopyridin-2-yl)-4-isopropylpiperazine 
• 686721-37-9 4-(4-isopropylpiperazine-1-carbonyl)benzaldehyde 
• 686720-98-9 (4-isopropylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone 
• 929622-23-1 (4-((4-fluoropiperidin-1-yl)methyl)phenyl)(4-isopropylpiperazin-1-yl)methanone 
• 385844-35-9 1-[2-(4-Fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine 
• 941320-59-8 [4-(3-dimethylamino-1-hydroxy-propyl)-phenyl]-(4-isopropyl-piperazin-1-yl)-methanone 
• 941320-58-7 3-dimethylamino-1-[4-(4-isopropyl-piperazine-1-carbonyl)-phenyl]-propan-1-one 

Relevant academic research and scientific papers

NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES

The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES

The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES

Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

N-SUBSTITUTED DERIVATIVES OF (ALPHA)-MERCAPTO ALKYLAMINES, THEIR PREPARATION PROCESS AND THE INTERMEDIATES OBTAINED, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM

Novel α-mercapto-alkylamines in all possible racemic, enantiomeric and diastereoisomeric forms of the formula STR1 wherein n, R 1, R 2, X, A, R 3A and R 4A are set forth in the claims and their non-toxic, pharmaceutically acceptable acid addition salts having excellent analgesic, psychotropic and enkephalinase inhibiting properties.

Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof

This invention relates to tri- and tetra-substituted-oxetanes, e.g. (±)-cis- and (±)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-dihalophenyl)-4-[1H-1,2,4-triazol-1-yl)-methyl]oxetane and tri- and tetra-substituted-tetrahydrofurans, e.g. (±)-cis- and (±)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1H-azol-1-yl)methyl]-5-furanylmethoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.

Tri- and tetra-substituted-oxetanes and -tetrahydrofurans and intermediates thereof

This invention relates to tri- and tetra--substituted-oxetanes of the formula,e.g. (±)-cis- and (±)-trans-2-[(4--(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4--dihalophenyl)-4-[1H-1,2,4-triazol-1-yl)methyl]oxetane and tri- and tetra- substituted-tetrahydrofurans, e.g. (±)--cis- and (±)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro--2-[(1H-azol-1-yl)methyl]-5-furanyl]methoxy]phenyl]-4-yl--1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.