88576-79-8

Basic information

• Product Name: L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N-[2-oxo-1-(phenylmethyl) propyl]-, (S)-
• CAS NO: 88576-79-8
• Molecular Formula: C27H34N4O6
• Molecular Weight: 510.59
• Mol File: 88576-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N-[2-oxo-1-(phenylmethyl) propyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N-[2-oxo-1-(phenylmethyl) propyl]-, (S)-(88576-79-8)
• EPA Substance Registry System: L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N-[2-oxo-1-(phenylmethyl) propyl]-, (S)-(88576-79-8)

Safety Data

• Hazardous Substances Data: 88576-79-8(Hazardous Substances Data)

Upstream product

• 111491-96-4 (S)-3-(N-(benzyloxycarbonyl)amino)-4-phenyl-2-butanone 
• 13585-98-3 N^α-benzyloxycarbobyl-L-alanyl-L-alanyl-L-alanine 
• 36979-87-0 Phenylalanylmethane hydrochloride 

Downstream Products

• 88576-80-1 Z-Glp-Ala₃-PheCH₃ 
• 90427-69-3 Glp-Ala₃-PheCH₃ 
• 90427-67-1 Ac-Ala₃-PheCH₃ 
• 90427-76-2 Ala₃-PheCH₃, HBr 

Relevant articles and documents

Thermitase - A Thermostable Serine Protease. III. Synthesis of N-Acylated Peptide Methyl Ketones as Inhibitors Reversibly Bound to the Enzyme

Methyl ketone derivatives of dipeptides to pentapeptides are used as suitable tools in the investigation of the non-covalent binding for subsite mapping of the active site of the enzyme.The synthesis is mainly performed by fragment condensation of N-acylated peptides or amino acids with methyl ketone derivatives of amino acids.These are prepared from the Z-protected chloromethyl ketones by catalytic hydrogenation.For the coupling steps the Z-protection is preferred.The peptide methyl ketones used in kinetic studies were N-protected by the Z, acetyl, Boc or pyroglutamyl residue.