885936-49-2Relevant academic research and scientific papers
Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors
Huang, Wenwei,Huang, Ruili,Attene-Ramos, Matias S.,Sakamuru, Srilatha,Englund, Erika E.,Inglese, James,Austin, Christopher P.,Xia, Menghang
supporting information; experimental part, p. 5239 - 5243 (2011/10/02)
Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1α transcriptional factor from a high-throughput screen. HIF-1α up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the synthes
