886-33-9

Upstream product

• 92022-50-9 1-bromo-2-((phenylsulfonyl)methyl)benzene 
• 1122-91-4 4-bromo-benzaldehyde 
• 91110-68-8 1-bromo-4-((phenylsulfonyl)methyl)benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 583-55-1 1-Bromo-2-iodobenzene 

Downstream Products

• 792-61-0 2,4'-Tolan-dicarbonsaeure 
• 964-39-6 4-[(3-oxo-3H-isobenzofuran-1-ylidene)methyl]benzoic acid 
• 1370372-11-4 1-((4-bromophenyl)ethynyl)-2-ethynylbenzene 

Relevant academic research and scientific papers

The Direct Conversion of α-Hydroxyketones to Alkynes

Alkynes are highly important functional groups in organic chemistry, both as part of target structures and as versatile synthetic intermediates. In this study, a protocol for the direct conversion of α-hydroxyketones to alkynes is reported. In combination with the variety of synthetic methods that generate the required starting materials by forming the central C-C bond, it enables a highly versatile fragment coupling approach toward alkynes. A broad scope for this novel transformation is shown alongside mechanistic insights. Furthermore, the utility of our protocol is demonstrated through its application in concert with varied α-hydroxyketone syntheses, giving access to a broad spectrum of alkynes.

Synthesis of Naphthalenyl Triflates via the Cationic Annulation of Benzodiynes with Triflic Acid

A highly efficient and regioselective annulation of benzodiynes promoted by triflic acid has been developed. This protocol provides a step and atom-economic access to a series of naphthalenyl triflates. Furthermore, direct synthetic applications of this r

Double elimination protocol for convenient synthesis of dihalodiphenylacetylenes: Versatile building blocks for tailor-made phenylene-ethynylenes

Dihalodiphenylacetylenes are conveniently synthesized by a double elimination reaction of β-substituted sulfones which are readily obtained from halogen-substituted benzyl sulfone and benzaldehyde derivatives. Halogens can be incorporated at any desired positions in the diphenylacetylene skeleton simply by choosing the substitution position of the halogen on the aromatic rings of the starting compounds. The diphenylacetylenes with different halogen substituents thus obtained undergo sequential carbon-carbon bond formations due to the different reactivities of the halogens. Thus, various moieties can be incorporated on the diphenylacetylene skeleton at whichever positions so that a variety of tailor-made phenylene-ethynylenes with regulated structure and composition could be designed.