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Upstream product

• 792-61-0 2,4'-Tolan-dicarbonsaeure 
• 886-33-9 1-(2-bromophenyl)-2-(4-bromophenyl)ethyne 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 61260-15-9 dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate 
• 619-66-9 4-Carboxybenzaldehyde 

Relevant academic research and scientific papers

Phthalazone or phthalazinylphenol derivatives and application thereof

The invention relates to the technical field of chemical synthesis, in particular to phthalazone or phthalazinylphenol derivatives serving as PARP and HDACs double-target inhibitors and application thereof, and aims at providing phthalazone derivatives or phthalazinylphenol derivatives serving as a kind of novel PARP and HDACs double-target inhibitors. The structures of phthalazone or phthalazinylphenol derivatives are shown in formula I or formula II. Phthalazone or phthalazinylphenol derivatives have significant activity of inhibiting poly(ADP-ribose)polymerase and histone deacetylase and have effective anti-tumor effects; new choices are provided for developing and applying anti-tumor drugs related to inhibiting activity of poly(ADP-ribose)polymerase and histone deacetylase. (The formulae are shown in the description.).