886047-22-9 Usage
Uses
Used in Pharmaceutical Industry:
3-aMino-5-chloro-N-cyclopropyl-4-Methyl-6-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)thieno[2,3-b]pyridine-2-carboxaMide is used as an anti-psychotic agent for the treatment of schizophrenia. It acts as a novel positive allosteric modulator, enhancing the activity of acetylcholine and other mAChR agonists at M2 and M4 receptors, which can help improve cognitive function and reduce positive and negative symptoms associated with schizophrenia.
references
[1]. croy ch, schober da, xiao h, et al. characterization of the novel positive allosteric modulator, ly2119620, at the muscarinic m(2) and m(4) receptors. mol pharmacol, 2014, 86(1): 106-115. kruse ac, ring am, manglik a, et al. activation and allosteric modulation of a muscarinic acetylcholine receptor. nature, 2013, 504(7478): 101-106.schober da, croy ch, xiao h, et al. development of a radioligand, [(3)h]ly2119620, to probe the human m(2) and m(4) muscarinic receptor allosteric binding sites. mol pharmacol, 2014, 86(1): 116-123.
Check Digit Verification of cas no
The CAS Registry Mumber 886047-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,0,4 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 886047-22:
(8*8)+(7*8)+(6*6)+(5*0)+(4*4)+(3*7)+(2*2)+(1*2)=199
199 % 10 = 9
So 886047-22-9 is a valid CAS Registry Number.
886047-22-9Relevant academic research and scientific papers
THIENOPYRIDINES AS ALLOSTERIC POTENTIATORS OF THE M4 MUSCARINIC RECEPTOR
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Page/Page column 21-22, (2008/06/13)
The present invention relates to selective allosteric potentiators of the Formula (I): or pharmaceutically acceptable salts thereof, for the treatment of disorders associated with M4 muscarinic receptors.
