886053-73-2 Usage
Uses
Used in Pharmaceutical Research and Development:
(6-cyclohexylcarbamoyl-[(4-methoxy-benzyl)-(pyridine-2-carbonyl)-amino]-methyl-naphthalen-2-yloxy)-acetic acid tert-butyl ester is used as a compound in pharmaceutical research and development for its potential to be modified and utilized in the creation of new drugs. Its complex structure and various functional groups may allow for interactions with biological targets, making it a candidate for further study.
Used in Organic Synthesis:
In the field of organic synthesis, (6-cyclohexylcarbamoyl-[(4-methoxy-benzyl)-(pyridine-2-carbonyl)-amino]-methyl-naphthalen-2-yloxy)-acetic acid tert-butyl ester is used as a building block or intermediate for the synthesis of more complex organic molecules. Its unique structure can be a starting point for creating novel compounds with specific properties and applications.
Used in Chemical Biology:
(6-cyclohexylcarbamoyl-[(4-methoxy-benzyl)-(pyridine-2-carbonyl)-amino]-methyl-naphthalen-2-yloxy)-acetic acid tert-butyl ester is used as a probe in chemical biology to investigate the interactions between small molecules and biological systems. Its structural features may enable it to serve as a tool for understanding biological processes at the molecular level.
Used in Application Industry:
(6-cyclohexylcarbamoyl-[(4-methoxy-benzyl)-(pyridine-2-carbonyl)-amino]-methyl-naphthalen-2-yloxy)-acetic acid tert-butyl ester is used as [application type] for [application reason]. (Note: The specific application type and reason would depend on the industry and the compound's properties as they are further characterized and understood.)
Check Digit Verification of cas no
The CAS Registry Mumber 886053-73-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,0,5 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 886053-73:
(8*8)+(7*8)+(6*6)+(5*0)+(4*5)+(3*3)+(2*7)+(1*3)=202
202 % 10 = 2
So 886053-73-2 is a valid CAS Registry Number.
886053-73-2Relevant academic research and scientific papers
Xu, Yang,Shi, Jin,Yamamoto, Noboru,Moss, Jason A.,Vogt, Peter K.,Janda, Kim D.
, p. 2660 - 2673 (2006)
Protein-protein interfaces are prominent in many therapeutically important targets. Using small organic molecules to disrupt protein-protein interactions is a current challenge in chemical biology. An important example of protein-protein interactions is provided by the Myc protein, which is frequently deregulated in human cancers. Myc belongs to the family of basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors. It is biologically active only as heterodimer with the bHLH-ZIP protein Max. Herein, we report a new strategy for the disruption of protein-protein interactions that has been corroborated through the design and synthesis of a small parallel library composed of 'credit-card' compounds. These compounds are derived from a planar, aromatic scaffold and functionalized with four points of diversity. From a 285 membered library, several hits were obtained that disrupted the c-Myc-Max interaction and cellular functions of c-Myc. The IC50 values determined for this small focused library for the disruption of Myc-Max dimerization are quite potent, especially since small molecule antagonists of protein-protein interactions are notoriously difficult to find. Furthermore, several of the compounds were active at the cellular level as shown by their biological effects on Myc action in chicken embryo fibroblast assays. In light of our findings, this approach is considered a valuable addition to the armamentarium of new molecules being developed to interact with protein-protein interfaces. Finally, this strategy for disrupting protein-protein interactions should prove applicable to other families of proteins.
