88611-29-4Relevant academic research and scientific papers
A Direct Access to 3-(2-Oxoalkyl)indoles via Aluminum Chloride Induced C-C Bond Formation
Pal, Manojit,Dakarapu, Rambabu,Padakanti, Srinivas
, p. 2913 - 2916 (2007/10/03)
3-Methylindole is acylated regioselectively at the methyl group when treated with a variety of acyl chlorides in 1,2-dichloroethane in the presence of AlCl3, affording a mild and direct method for the synthesis of 3-(2-oxoalkyl)-indoles. The product formation in this one-pot reaction largely depends on the conditions of the reaction employed. The methodology does not require protection-deprotection steps and is amenable for the scale-up synthesis of these indole derivatives.
