88611-45-4

Upstream product

• 591-51-5 phenyllithium 
• 162375-31-7 N-iso-propyl-Z-3-chloro-2-(phenylthio)propenamide 
• 75-31-0 isopropylamine 
• 637-44-5 phenylpropyolic acid 
• 536-74-3 phenylacetylene 
• 693-13-0 diisopropyl-carbodiimide 

Downstream Products

• 1174523-71-7 (R)-8a-(but-3-enyl)-N-isopropyl-7-oxo-5-phenyl-1,2,3,7,8,8a-hexahydroindolizine-6-carboxamide 
• 1174523-70-6 (R)-N-isopropyl-7-oxo-5-phenyl-1,2,3,7,8,8a-hexahydroindolizine-6-carboxamide 
• 1263037-04-2 (Z)-5-benzylidene-3-isopropyloxazolidine-2,4-dione 
• 1620886-78-3 (Z)-3-chloro-N-isopropyl-3-phenyl-2-((tetrahydrofuran-2-yl)methyl)acrylamide 
• 23784-47-6 (2E)-N-isopropyl-3-phenylacrylamide 

Relevant academic research and scientific papers

Alkynylboration Reaction Leading to Boron-Containing π-Extended cis-Stilbenes as a Highly Tunable Fluorophore

An unprecedented boron-containing fluorophore, π-extended cis-stilbene, obtained via alkynylboration reaction of alkynamide is reported. Boron-containing π-extended cis-stilbenes emit fluorescence with high quantum yields in the solid state and exhibit aggregation-induced emission enhancement. The broad substrate scope of the alkynylboration reaction offers facile access to electronically diverse structures, enabling fine-tuning of light absorption/emission characteristics. The boron-containing π-extended cis-stilbene with a diphenylamino group displays solvatofluorochromism via an intramolecular charge-transfer transition.

Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles

Synthetically versatile conjugate addition of a range of carbon, nitrogen, oxygen, sulfur and selenium nucleophiles to the highly functionalised 2-thio-3-chloroacrylamides is described. The stereochemical and synthetic features of this transformation are discussed in detail. In most instances, the nucleophile replaces the chloro substituent with retention of stereochemistry. With the oxygen nucleophiles, a second addition can occur leading to acetals, while with the nitrogen nucleophiles, E-Z isomerism occurs in the resulting enamine derivatives. The ratio of the E/Z isomers can be rationalised on the basis of the substituent and the level of oxidation.

Catalytic addition of terminal alkynes to carbodiimides by half-sandwich rare earth metal complexes

The catalytic addition of terminal alkynes to carbodiimides has been achieved for the first time by use of half-sandwich rare earth metal complexes, such as {Me2Si(C5Me4)(NPh)}Y(CH2SiMe3)(THF)2/