88611-69-2Relevant academic research and scientific papers
Organocatalytic Michael addition/intramolecular Julia-Kocienski olefination for the preparation of nitrocyclohexenes
Rodrigo, Eduardo,Garcia Ruano, Jose Luis,Cid, M. Belen
, p. 10737 - 10746 (2013/11/19)
An asymmetric organocatalytic [3 + 3] annulation strategy based on a Michael addition/intramolecular Julia-Kocienski olefination sequence has been developed for the synthesis of 4-substituted-5-nitrocyclohex-1-ene compounds. The strategy is an alternative to the direct reluctant enantioselective Diels-Alder approach. The potential of the methodology has been demonstrated with a concise enantioselective formal synthesis of trandolapril.
Structure-activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells
Young, David H.,Tice, Colin M.,Michelotti, Enrique L.,Roemmele, Renee C.,Slawecki, Richard A.,Rubio, Fernando M.,Rolling, Judith A.
, p. 1393 - 1396 (2007/10/03)
Phenylcyclohexenes (PCHs) [e.g., trans-4-nitro-5-(2,3,4-trimethoxyphenyl)cyclohexene, 2d] were found to bind weakly to the colchicine site of bovine tubulin, but are the first mimics of colchicine found to have high activity towards plant cells. Structure
