886230-72-4Relevant academic research and scientific papers
Method for preparing 2,6-diethyl-4-methyl phenylacetic acid
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Page/Page column 6-8, (2019/10/23)
The invention relates to the field of organic synthesis, in particular to a method for preparing a pinoxaden intermediate (2,6-diethyl-4-methyl) phenylacetic acid. The method comprises the following steps: carrying out a Meerwein arylation reaction and a vinyl acetate reaction on 2,6-diethyl-4-methylaniline, so as to produce 1-ethoxycarbonyl-1-chloro-2-(2,6-diethyl-4-methylphenyl) ethane; hydrolyzing the 1-ethoxycarbonyl-1-chloro-2-(2,6-diethyl-4-methylphenyl) ethane to produce 2,6-diethyl-4-methyl-benzeneacetaldehyde under an acidic condition; carrying out a NaClO2 oxidizing reaction on the 2,6-diethyl-4-methyl-benzeneacetaldehyde, so as to produce the 2,6-diethyl-4-methyl phenylacetic acid. The method disclosed by the invention has the advantages that use of any expensive precious metalcatalyst or highly toxic cyanide reagent is avoided, the used reagent is environmentally-friendly, the cost is reduced, the process is simplified, the yield is high, defects in the prior art are overcome, and the method is suitable for large-scale industrial production.
Synthesis method of pinoxaden intermediate (2, 6-diethyl-4-methyl)phenylacetic acid
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, (2019/05/08)
The invention relates to the field of organic synthesis, in particular to a synthesis method of a pinoxaden intermediate (2, 6-diethyl-4-methyl)phenylacetic acid. The method includes: letting 2, 6-diethyl-4-methylaniline, hydrobromic acid and sodium nitri
Method for preparing pinoxaden key intermediate
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, (2019/01/16)
The invention discloses a method for preparing a pinoxaden key intermediate. The method includes step 1 of utilizing 2,6-diethyl-4-methylbromobenzene as a raw material and first undergoing reaction with a magnesium strip in a tetrahydrofuran solvent to pr
METHOD FOR PRODUCING 2,6-DIETHYL-4-METHYLPHENYLACETIC ACID
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Paragraph 0032, (2013/06/27)
A method for producing 2,6-diethyl-4-methylphenylacetic acid comprising a step of reacting a 2,6-diethyl-4-methylphenyl magnesium halide with ethylene oxide to obtain 2-(2,6-diethyl-4-methylphenyl) ethanol; and a step of oxidizing 2-(2,6-diethyl-4-methylphenyl) ethanol. The oxidation is conducted preferably further in the presence of a nitroxyl radical, and more preferably in the presence of a salt of a hypohalous acid and/or a salt of a halous acid.
Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden
Muehlebach, Michel,Boeger, Manfred,Cederbaum, Fredrik,Cornes, Derek,Friedmann, Adrian A.,Glock, Jutta,Niderman, Thierry,Stoller, Andre,Wagner, Trixie
experimental part, p. 4241 - 4256 (2009/10/02)
Derivatives of the new class of 3-hydroxy-4-phenyl-5-oxo-pyrazolines were optimized towards both herbicidal activity on key annual grass weed species and selectivity in small grain cereal crops. The generic structure can be separated into three parts for the analysis of the structure-activity relationships, namely the aryl, the dione with its prodrug forms and the hydrazine moiety. Each area appears to play distinct and different roles in overall expression of biological performance which is further beneficially influenced by adjuvant response and safener action. Pinoxaden 6, a novel graminicide for use in wheat and barley incorporating a [1,4,5]oxadiazepane ring, eventually emerged as a development candidate from the discovery and optimization process.
2,6-DIETHYL-4-METHYL-PHENYL-SUBSTITUTED TETRAMIC ACID DERIVATIVES
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Page/Page column 102, (2008/06/13)
The invention relates to the novel 2,6-diethyl-4-methyl-phenyl-substituted tetramic acid derivatives of formula (I), wherein A, B, D and G are defined as above. The invention also relates to several methods and intermediate products for producing said der
