886366-42-3

Basic information

• Product Name: 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 4-(4-METHOXYPHENYL)THIAZOLE-2-CARBOXYLATE;Ethyl 4-(4-methoxyphenyl)-1,3-thiazole-2-carboxylate
• CAS NO: 886366-42-3
• Molecular Formula: C₁₃H₁₃NO₃S
• Molecular Weight: 263.31
• Mol File: 886366-42-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(886366-42-3)
• EPA Substance Registry System: 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(886366-42-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 886366-42-3(Hazardous Substances Data)

Usage

General Description

4-(4-Methoxy-phenyl)-thiazole-2-carboxylic acid ethyl ester is a chemical compound with a molecular formula C13H13NO3S. It is an ester derivative of a thiazole carboxylic acid, and it is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 4-(4-METHOXY-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER has potential biomedical applications and has been investigated for its antibacterial and antitumor properties. It is also used as a research tool in the study of thiazole derivatives and their biological activities. Additionally, its unique structure and properties make it a valuable tool for drug discovery and development.

Upstream product

• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 123971-42-6 4-(4-methoxyphenyl)thiazole-2-carboxylic acid 
• 1826-21-7 4-(4-methoxy-phenyl)-thiazole 

Relevant articles and documents

Identification of potent α-amylase inhibitors via dynamic combinatorial chemistry

In this study, we report for the first time the discovery of potent α-amylase inhibitors using principle of dynamic combinatorial chemistry. The best compound identified exhibited not only high inhibitory efficiency but also low cytotoxicity. The binding mode and possible mechanism are determined in the subsequent kinetic and molecular docking studies.

Design, synthesis, and biological evaluation of N,N-disubstituted-4-arylthiazole-2-methylamine derivatives as cholesteryl ester transfer inhibitors

Cholesteryl ester transfer protein (CETP) has been identified as a potential target for cardiovascular disease (CVD) for its important role in the reverse cholesteryl transfer (RCT) process. In our previous work, compound 5 was discovered as a moderate CETP inhibitor. The replacement of the amide linker by heterocyclic aromatics and then a series of N,N-substituted-4-arylthiazole-2-methylamine derivatives were designed by utilizing a conformational restriction strategy. Thirty-six compounds were synthesized and evaluated for their CETP inhibitory activities. Structure-activity relationship studies indicate that electron donor groups substituted ring A, and electron-withdrawing groups at the 4-position of ring B were critical for potency. Among these compounds, compound 30 exhibited excellent CETP inhibitory activity (IC50 = 0.79 ± 0.02 μM) in vitro and showed an acceptable metabolic stability.

Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors

A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivatives, (3R)-3-amino-N-(4-(4-phenylthiazol-2-yl)-tetrahydro-2H- thiopyran-4-yl)-4-(2,4,5-trifluorophenyl)butanamide 1,1-dioxide (30) reduced blood glucose excursion in an oral glucose tolerance test by oral administration.