886447-76-3

Upstream product

• 40350-83-2 (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 59184-90-6 ethyl (piperidin-4-yl)acetate 
• 902770-73-4 ethyl [1-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate 
• 903499-14-9 ethyl [1-[(4R)-benzyloxy-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate 
• 903499-17-2 ethyl [1-[(4R)-benzyloxy-1-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate 

Relevant academic research and scientific papers

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists

A series of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives were synthesized and evaluated for their activity as VLA-4 antagonists. Of 22 compounds synthesized, 19 compounds showed potent activity with low nanomolar IC50 values. In addition, the representative compounds 11o and 11p with a hydroxy group in the pyrrolidine ring showed moderate plasma clearance in rats (11o, 30 ml/min/kg and 11p, 21 ml/min/kg) and in dogs (11o, 12 ml/min/kg and 11p, 9 ml/min/kg).