903499-14-9

Basic information

• Product Name: ethyl [1-[(4R)-benzyloxy-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate
• Synonyms: ethyl [1-[(4R)-benzyloxy-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate
• CAS NO: 903499-14-9
• Molecular Weight: 374.48
• Mol File: 903499-14-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl [1-[(4R)-benzyloxy-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [1-[(4R)-benzyloxy-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate(903499-14-9)
• EPA Substance Registry System: ethyl [1-[(4R)-benzyloxy-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate(903499-14-9)

Safety Data

• Hazardous Substances Data: 903499-14-9(Hazardous Substances Data)

Upstream product

• 40350-83-2 (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 59184-90-6 ethyl (piperidin-4-yl)acetate 
• 902770-73-4 ethyl [1-[(4R)-benzyloxy-1-(tert-butoxycarbonyl)-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate 

Downstream Products

• 886447-76-3 [1-((2S,4R)-4-Benzyloxy-1-{2-[3-methoxy-4-(3-o-tolyl-ureido)-phenyl]-acetyl}-pyrrolidine-2-carbonyl)-piperidin-4-yl]-acetic acid 
• 903499-17-2 ethyl [1-[(4R)-benzyloxy-1-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinylcarbonyl]-4-piperidinyl]acetate 

Relevant articles and documents

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists

A series of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives were synthesized and evaluated for their activity as VLA-4 antagonists. Of 22 compounds synthesized, 19 compounds showed potent activity with low nanomolar IC50 values. In addition, the representative compounds 11o and 11p with a hydroxy group in the pyrrolidine ring showed moderate plasma clearance in rats (11o, 30 ml/min/kg and 11p, 21 ml/min/kg) and in dogs (11o, 12 ml/min/kg and 11p, 9 ml/min/kg).