886465-16-3

Usage

General Description

1H-Benzimidazole, 2-chloro-5-(trifluoromethoxy)-, also known as rabeprazole, is a proton pump inhibitor used to decrease the amount of acid produced in the stomach. It is commonly prescribed to treat conditions such as gastroesophageal reflux disease (GERD) and ulcers. Rabeprazole works by inhibiting the enzyme that produces stomach acid, which can help to relieve symptoms such as heartburn and acid indigestion. It is available in both prescription and over-the-counter forms and is generally well-tolerated, though there may be some potential side effects such as headache, diarrhea, and abdominal pain.

Upstream product

• 877681-12-4 5-(trifluoromethoxy)-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 658-89-9 4-(trifluoromethoxy)benzene-1,2-diamine 
• 2267-23-4 2-nitro-4-trifluoromethoxyaniline 

Downstream Products

• 1073559-38-2 3-phenyl-8-{5-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}-1-oxa-3,8-diazaspiro-[4.5]decan-2-one 
• 1073558-81-2 3-phenyl-8-{5-[(trifluoromethyl)oxy]-1H-benzimidazol-2-yl}-1-oxa-3,8-diazaspiro-[4.5]decan-2-one hydrochloride 

Relevant academic research and scientific papers

CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30

The present invention relates to a class of substituted-cyanopyrrolidines of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility i

BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salts, solvates, stereoisomers thereof, formula (I), R1 may be C1-C4 alkyl, aryl or heteroaryl, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; R2 may be halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano, nitro; or aryl, heteroaryl or heterocycle, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; or R2 may correspond to -0-R3; R3 is a 6-membered aromatic carbocyclic ring which may contain 1 or 2 nitrogen X is carbon or oxygen; Z is carbon or nitrogen; G is a fused 6-membered aromatic carbocyclic ring which may contain 1 or 2 nitrogen; m may be 0 or an integer ranging from 1 to 4; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY- Y5 receptor antagonists.

PROPARGYL TRIFLUOROMETHOXY AMINOBENZIMIDAZOLE DERIVATIVES

Disclosed are compounds having the structure: wherein X is a) where R1 is H, C1-C6 alkyl, C3-C6 alkenyl, or C3-C6 alkynyl; R2 is H or C1-C4 alkyl