886466-24-6Relevant articles and documents
Kinetic resolution displaying zeroth order dependence on substrate consumption: Copper-catalyzed asymmetric alcoholysis of azlactones
Tokunaga, Makoto,Kiyosu, Junya,Obora, Yasushi,Tsuji, Yasushi
, p. 4481 - 4486 (2007/10/03)
Kinetic resolution of 4-alkyl-2-aryl-5-oxo-4,5-dihydrooxazole-4-carboxylic acid esters (azlactones 1) were achieved by copper-DTBM-SEGPHOS catalyzed alcoholysis reaction with good selectivity (12 examples). Variation of ee of unreacted substrates 1 and pr