886466-35-9Relevant academic research and scientific papers
Metal complexes-catalyzed hydrolysis and alcoholysis of organic substrates and their application to kinetic resolution
Tokunaga, Makoto,Aoyama, Hiroshi,Kiyosu, Junya,Shirogane, Yuki,Iwasawa, Tetsuo,Obora, Yasushi,Tsuji, Yasushi
, p. 472 - 480 (2008/02/06)
Metal complexes-catalyzed hydrolysis and alcoholysis of organic substrates such as alkenyl esters, alkenyl ethers, and azlactones (oxazol-5(4H)-ones) are described. These reactions were applied for kinetic resolution of chiral compounds and high selectivities were achieved with vinyl ethers of 2-substituted cyclohexanols, 1,1′-bi-2-naphthols, 1,1′-bi-2-phenols, and 4,4-disubstituted azlactones. Oxidative carbon-carbon bond cleavage reactions, which were found in the course of the study of asymmetric hydrolysis were also described.
Kinetic resolution displaying zeroth order dependence on substrate consumption: Copper-catalyzed asymmetric alcoholysis of azlactones
Tokunaga, Makoto,Kiyosu, Junya,Obora, Yasushi,Tsuji, Yasushi
, p. 4481 - 4486 (2007/10/03)
Kinetic resolution of 4-alkyl-2-aryl-5-oxo-4,5-dihydrooxazole-4-carboxylic acid esters (azlactones 1) were achieved by copper-DTBM-SEGPHOS catalyzed alcoholysis reaction with good selectivity (12 examples). Variation of ee of unreacted substrates 1 and pr
