886495-82-5

Upstream product

• 121-90-4 m-nitrobenzoic acid chloride 
• 70102-34-0 3-nitrothiobenzamide 
• 645-09-0 3-nitrobenzamide 
• 619-41-0 4-(bromoacetyl)toluene 
• 1387385-55-8 2-(3-nitrophenyl)-4-p-tolylthiazole 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 1418206-32-2 2-(3,4-dimethoxyphenyl)-N-(3-(4-p-tolylthiazol-2-yl)phenyl)acetamide 

Relevant academic research and scientific papers

Design, synthesis and biological activity evaluation of 2,5-diphenyl-1,3,4-oxadiazole derivatives as novel inhibitors of fructose-1,6-bisphosphatase

Fructose-1,6-bisphosphatase (FBPase), an important gluconeogenic enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. The effort to discover new FBPase inhibitors was carried out by high-throughput screening (HTS) of a library of 56,000 lead-like compounds, and a 2,5-diphenyl-1,3,4-oxadiazole (3a, IC50 = 15.45 μM) which bearing no phosphate group was identified as a potential FBPase inhibitor for the first time. Structure-activity-relationship (SAR) research of a series of analogues obtained by modifying the substituent groups and replacing the 1,3,4-oxadiazole with several other heterocycles disclosed the key structure and substituent groups related to the binding with FBPase.