886497-07-0

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Chloro-5-(trifluoromethyl)anisole is employed as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Production:
3-CHLORO-5-(TRIFLUOROMETHYL)ANISOLE is also utilized in the production of agrochemicals, playing a crucial role in the creation of effective pesticides and other agricultural chemicals to protect crops and enhance agricultural productivity.
Used in Specialty Chemicals Manufacturing:
3-Chloro-5-(trifluoromethyl)anisole finds application in the manufacturing of specialty chemicals, which are high-value products used in various industries such as coatings, adhesives, and fragrances.
Used in Organic Synthesis:
Due to its high reactivity, 3-chloro-5-(trifluoromethyl)anisole is widely used in organic synthesis for the preparation of various chemical compounds, including those with potential applications in the chemical, pharmaceutical, and materials science industries.

InChI:InChI=1/C8H6ClF3O/c1-13-7-3-5(8(10,11)12)2-6(9)4-7/h2-4H,1H3

Upstream product

• 479411-93-3 2-(3-methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 887144-97-0 Togni's reagent 
• 929626-16-4 2-(3-chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 2845-89-8 1-chloro-3-methoxy-benzene 

Downstream Products

• 1414931-83-1 2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid 
• 1414931-41-1 3-(2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoic acid 
• 1414931-72-8 2-chloro-6-methoxy-4-trifluoromethylbenzaldehyde 
• 1414931-75-1 Ethyl 3-(2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate 
• 1414931-74-0 methyl 2'-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate 
• 1415128-96-9 3-(5-(2-(((2-chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methoxy-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid 
• 1415130-79-8 ethyl 3-(5-(2-(((2-chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methoxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate 
• 1415130-78-7 ethyl 3-(5-(2-formyl-3-methoxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate 

Relevant academic research and scientific papers

Highly selective trifluoromethylation of 1,3-disubstituted arenes through iridium-catalyzed arene borylation

The old one two: A sequential iridium-catalyzed borylation and copper-catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. T

Meta halogenation of 1,3-disubstituted arenes via iridium-catalyzed arene borylation

We report the meta halogenation of 1,3-disubstituted arenes to form 3,5-disubstituted aryl bromides and chlorides by using iridium-catalyzed arene borylation chemistry. Iridium-catalyzed borylation of arenes with B2pin2, followed by reaction of the boronic ester with copper(II) bromide or chloride converts arylboronic esters to the corresponding aryl halides. A variety of arenes containing alkoxy, alkyl, halogen, nitrile, ester, amide, and pivaloyl and TIPS-protected alcohols were converted to the corresponding 3,5-disubstituted aryl bromides and chlorides in yields ranging from 46% to 85%. In addition, 2,6-disubstituted and 3-substituted pyridines were converted to the 4-halo and 5-halopyridines, respectively. The utility of this methodology was demonstrated by the formal conversion of nicotine to Altinicline in three steps with an overall yield of 61% using meta bromination of nicotine as the first step. Copyright