886500-21-6

Basic information

• Product Name: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL
• Synonyms: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL
• CAS NO: 886500-21-6
• Molecular Formula: C₈H₆ClF₃O
• Molecular Weight: 210.58
• Mol File: 886500-21-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 214.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.416±0.06 g/cm3(Predicted)
• PKA: 13.63±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL(886500-21-6)
• EPA Substance Registry System: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL(886500-21-6)

Safety Data

• Hazardous Substances Data: 886500-21-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-(trifluoromethyl)benzyl alcohol is a chemical compound with the molecular formula C8H6ClF3O. It is a colorless liquid with a molecular weight of 198.58 g/mol. 2-CHLORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a solvent in various chemical reactions and processes. 2-Chloro-6-(trifluoromethyl)benzyl alcohol is considered to be a hazardous substance and should be handled with care due to its potential health and environmental risks.

Upstream product

• 916420-44-5 2-chloro-6-(trifluoromethyl)benzoyl chloride 
• 1214386-37-4 methyl 2-chloro-6-(trifluoromethyl)benzoate 
• 2376-00-3 2-chloro-6-(trifluoromethyl)benzoic acid 

Downstream Products

• 60611-22-5 2-chloro-6-(trifluoromethyl)benzaldehyde 
• 1175300-52-3 1-(2-chloro-6-(trifluoromethyl)phenyl)ethanol 

Relevant articles and documents

5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY

The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.

N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORGAMMAT INHIBITORS AND USES THEREOF

Disclosed are compounds of Formula I or a pharmaceutically acceptable salt or solvate thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.