886501-50-4 Usage
Uses
Used in Pharmaceutical Industry:
4-Chloro-3-(trifluoromethoxy)benzonitrile is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-3-(trifluoromethoxy)benzonitrile is utilized as a key intermediate in the synthesis of herbicides and pesticides. Its role in these applications is to provide a foundation for the development of effective and environmentally responsible crop protection products.
Used as a Reagent in Organic Synthesis:
4-Chloro-3-(trifluoromethoxy)benzonitrile is employed as a reagent in organic synthesis, specifically for the preparation of biologically active compounds. Its versatility in chemical reactions allows for the creation of a wide range of organic molecules with potential applications in various fields.
Overall, 4-Chloro-3-(trifluoromethoxy)benzonitrile's diverse applications across different industries underscore its importance as a synthetic building block and reagent, highlighting its contribution to the advancement of pharmaceuticals, agrochemicals, and organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 886501-50-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,5,0 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 886501-50:
(8*8)+(7*8)+(6*6)+(5*5)+(4*0)+(3*1)+(2*5)+(1*0)=194
194 % 10 = 4
So 886501-50-4 is a valid CAS Registry Number.
886501-50-4Relevant academic research and scientific papers
Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen
Ouyang, Yao,Qing, Feng-Ling,Xu, Xiu-Hua
supporting information, (2021/12/06)
Trifluoromethoxylated aromatics (ArOCF3) are valuable structural motifs in the area of drug discovery due to the enhancement of their desired physicochemical properties upon the introduction of the trifluoromethoxy group (CF3O). Although significant progress has been made recently in the introduction of CF3O group into aromatics, current methods either require the use of expensive trifluoromethoxylation reagents or require harsh reaction conditions. We present a conceptually new and operationally simple protocol for the direct C?H trifluoromethoxylation of (hetero)aromatics by the combination of the readily available trifluoromethylating reagent and oxygen under electrochemical reaction conditions. This reaction proceeds through the initial generation of CF3 radical followed by conversion to CF3O radical, addition to (hetero)aromatics and rearomatization. The utility of this electrochemical trifluoromethoxylation is illustrated by the direct incorporation of CF3O group into a variety of (hetero)aromatics as well as bio-relevant molecules.
