886522-22-1Relevant academic research and scientific papers
Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors
Shi, Mengxiao,Stauffer, Barbara,Bhat, Ramesh,Billiard, Julia,Ponce-de-Leon, Helga,Seestaller-Wehr, Laura,Fukayama, Shoichi,Mangine, Annamarie,Moran, Robert,Krishnamurthy, Girija,Bodine, Peter,Gopalsamy, Ariamala
scheme or table, p. 6337 - 6339 (2010/05/02)
Secreted frizzled related protein-1 (sFRP-1) inhibitors have the potential to be used for the treatment of osteoporosis or other bone related disorders, since the level of sFRP-1 affects osteoblast apoptosis and proliferation. From high throughput screening, we have identified a class of iminooxothiazolidines as sFRP-1 inhibitors. Structure-activity relationships were established for various regions of the scaffold along with the biochemical characterization of this class to probe selectivity, binding and ex vivo activity.
