88653-43-4Relevant academic research and scientific papers
1-Phenyl-: N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
Hu, Min-Qi,Li, Heng,Lin, Ying,Tang, Jie,Tang, Wei,Tong, Xian-Kun,Yang, Fan,Yu, Li-Fang,Zhang, Ying,Zuo, Jian-Ping
, p. 43299 - 43311 (2020/12/25)
Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs. This journal is
Aryloxy anilino propionic ester compound and application thereof as herbicide
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Paragraph 0223; 0225, (2016/10/09)
An aryloxy anilino propionic ester compound comprises the structure shown in the general formula (I), wherein Ar is aromatic heterocycle or fused heterocycle. Please see the specification for the chemical formula of the aromatic heterocycle and the chemical formula of the fused heterocycle, wherein R1, R2, R3 and R4 are one or more of H, halogen, nitro, methoxy group, methyl, methyl formate group, cyanogroup and trihalomethyl, R5 is the alkyl group on the linear chain or branched chain of H and C1-C4, hydrogen on the alkyl group is substituted by hydroxyl, carboxyl, mercapto group, amino, guanidyl and phenyl, and R6 is one of methyl, ethyl, butyl and the substance specified in the specification. The compound has the advantages that the characteristics of being efficient, capable of acting quickly and not prone to resistance generation of (aryloxy) phenoxypropionate herbicides can be maintained, amino acid functional groups in molecules can be designed to serve as adulterate amino acid so as to restrain the biosynthesis of protein of plants, and all weeds can be controlled.
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors
Khim, Seock-Kyu,Bauman, John,Evans, Jarred,Freeman, Beverly,King, Beverly,Kirkland, Thomas,Kochanny, Monica,Lentz, Dao,Liang, Amy,Mendoza, Lisa,Phillips, Gary,Tseng, Jih-Lie,Wei, Robert G.,Ye, Hong,Yu, Limei,Parkinson, John,Guilford, William J.
scheme or table, p. 3895 - 3898 (2009/04/07)
The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA4-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.
