88654-17-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-Methylpiperidine-4-carbothioamide is used as a building block for the synthesis of various pharmaceutical and agrochemical compounds. Its unique structure allows it to be a versatile component in the development of new drugs and agrochemicals, contributing to the advancement of these industries.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
In the field of organic chemistry, 1-methylpiperidine-4-carbothioamide is utilized as a chiral auxiliary. This application is significant for asymmetric synthesis, where the compound aids in the selective formation of enantiomers, which is crucial for producing biologically active molecules with desired properties.
Used in Neuroprotection Research:
1-Methylpiperidine-4-carbothioamide has been studied for its potential as a neuroprotective agent. Its biological activity makes it a candidate for further research into protecting neurons and potentially treating neurodegenerative diseases.
Used as an Enzyme Inhibitor:
1-methylpiperidine-4-carbothioamide has also been investigated for its potential as an inhibitor of certain enzymes, including cholinesterases and carbonic anhydrase. Inhibiting these enzymes could have therapeutic applications in various medical conditions, making 1-methylpiperidine-4-carbothioamide a valuable compound for enzyme research and drug development.

InChI:InChI=1/C7H14N2S/c1-9-4-2-6(3-5-9)7(8)10/h6H,2-5H2,1H3,(H2,8,10)

Upstream product

• 19172-47-5 Lawessons reagent 
• 62718-28-9 1-methylpiperidine-4-carboxamide 
• 39546-32-2 4-carboxamidopiperidine 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 214834-18-1 tert-butyl 4-carbamothioylpiperidine-1-carboxylate 
• 50-00-0 formaldehyd 

Relevant academic research and scientific papers

THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS

Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to methods for preventing, treating or ameliorating an MMP9 and/or MMP13 mediated syndrome, disorder or disease comprising administering to a subject in need thereof an effective amount of a compound listed in the examples section of this specification, or a form, composition or medicament thereof. Disorders treated and/or prevented include rheumatoid arthritis.

THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS

Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to bisthiazole I and its therapeutic and prophylactic uses, wherein the variables A, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

Substituted 1,3-thiazole compounds, their production and use

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

JNK INHIBITOR

The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.