62718-28-9

Basic information

• Product Name: 1-METHYLPIPERIDINE-4-CARBOXAMIDE
• Synonyms: N-METHYLPIPERIDINE-4-CARBOXAMIDE;1-METHYLPIPERIDINE-4-CARBOXAMIDE;4-Piperidinecarboxamide,1-methyl-(9CI);1-Methyl-4-PiperidinecarboxaMide;1-methylisonipecotamide
• CAS NO: 62718-28-9
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.2
• Product Categories: AMIDE;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 62718-28-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 286.1°C at 760 mmHg
• Flash Point: 126.8°C
• Appearance: /
• Density: 1.046g/cm³
• Vapor Pressure: 0.0027mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-METHYLPIPERIDINE-4-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLPIPERIDINE-4-CARBOXAMIDE(62718-28-9)
• EPA Substance Registry System: 1-METHYLPIPERIDINE-4-CARBOXAMIDE(62718-28-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 62718-28-9(Hazardous Substances Data)

Usage

General Description

1-Methylpiperidine-4-carboxamide, also known as N-methyl-4-piperidinamine, is a chemical compound with the molecular formula C8H16N2O. It is a derivative of piperidine, a cyclic amine, and is commonly used as a building block in the synthesis of pharmaceuticals and various organic compounds. This chemical is also used as a precursor in the manufacturing of drugs such as anesthetics and analgesics. N-Methyl-4-piperidinamine is a white crystalline solid with a molecular weight of 156.22 g/mol. It has a wide range of applications in the pharmaceutical and agrochemical industries, making it an important intermediate in the production of various chemical products.

InChI:InChI=1/C7H14N2O/c1-9-4-2-6(3-5-9)7(8)10/h6H,2-5H2,1H3,(H2,8,10)

Upstream product

• 39546-32-2 4-carboxamidopiperidine 
• 124-38-9 carbon dioxide 
• 1453-82-3 isonicotinamide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 74-88-4 methyl iodide 
• 1690-75-1 1-methyl-piperidine-4-carboxylic acid methyl ester 
• 50-00-0 formaldehyd 
• 7630-02-6 4-(methoxycarbonyl)-1-methylpyridinium iodide 

Downstream Products

• 41838-46-4 4-Amino-1-methylpiperidine 
• 20691-92-3 1-methylpiperidine-4-carbonitrile 
• 88654-17-5 1-methylpiperidine-4-carbothioamide 
• 55022-88-3 1-azabicyclo[2.2.2]octane-4-carboxylic acid 
• 112864-70-7 4-cyano-1-methyl-quinuclidinium; chloride 
• 65345-83-7 4-cyano-1-methyl-quinuclidinium; iodide 
• 20691-91-2 1-(1-methylpiperidin-4-yl)ethanone 
• 92040-00-1 (1-methylpiperidin-4-yl)(phenyl)methanone 
• 26458-78-6 4-cyanoquinuclidine 
• 1027041-17-3 4-[2-(1,4-dimethyl-piperidin-4-yl)-thiazol-4-yl]-benzoic acid 
• 7149-42-0 1-(1-methylpiperidin-4-yl)methanamine 

Relevant articles and documents

Electrochemical Reductive N-Methylation with CO2Enabled by a Molecular Catalyst

The development of benign methylation reactions utilizing CO2 as a one-carbon building block would enable a more sustainable chemical industry. Electrochemical CO2 reduction has been extensively studied, but its application for reductive methylation reactions remains out of the scope of current electrocatalysis. Here, we report the first electrochemical reductive N-methylation reaction with CO2 and demonstrate its compatibility with amines, hydroxylamines, and hydrazine. Catalyzed by cobalt phthalocyanine molecules supported on carbon nanotubes, the N-methylation reaction proceeds in aqueous media via the chemical condensation of an electrophilic carbon intermediate, proposed to be adsorbed or near-electrode formaldehyde formed from the four-electron reduction of CO2, with nucleophilic nitrogenous reactants and subsequent reduction. By comparing various amines, we discover that the nucleophilicity of the amine reactant is a descriptor for the C-N coupling efficacy. We extend the scope of the reaction to be compatible with cheap and abundant nitro-compounds by developing a cascade reduction process in which CO2 and nitro-compounds are reduced concurrently to yield N-methylamines with high monomethylation selectivity via the overall transfer of 12 electrons and 12 protons.

PYRAZOLOPYRIMIDINES AS CYCLIN-DEPENDENT KINASE INHIBITORS

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.