886580-17-2Relevant academic research and scientific papers
Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation
Tachi, Yukihiro,Dai, Wei-Min,Tanabe, Kazuhito,Nishimoto, Sei-Ichi
, p. 3199 - 3209 (2007/10/03)
A number of enediyne prodrugs 1-5 possessing an (E)-3-hydroxy-4-(2′- hydroxy-1′-phenylethylidene)cyclodeca-1,5-diyne scaffold have been synthesized via the Sonogashira coupling and an intramolecular Nozaki-Hiyama-Kishi reaction as the key steps. Upon incu
