886587-08-2Relevant academic research and scientific papers
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives
Freundlich, Joel S.,Yu, Min,Lucumi, Edinson,Kuo, MacK,Tsai, Han-Chun,Valderramos, Juan-Carlos,Karagyozov, Luchezar,Jacobs Jr., William R.,Schiehser, Guy A.,Fidock, David A.,Jacobus, David P.,Sacchettini, James C.
, p. 2163 - 2169 (2007/10/03)
2′-Substituted analogs of triclosan have been synthesized to target inhibition of the key malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of these compounds exhibit good potency (EC 50 500 nM) against
