886595-34-2Relevant academic research and scientific papers
Nucleophile-catalyzed, facile, and highly selective C-H activation of fluoroform with Pd(II)
Takemoto, Shin,Grushin, Vladimir V.
, p. 16837 - 16840 (2013)
Exceedingly facile (23 C) and chemoselective H-CF3 activation with [(dppp)Pd(Ph)(OH)] in the presence of a Lewis base promoter such as n-Bu3P leads to Pd-CF3 bond formation in nearly quantitative yield. A combined experimental and computational study points to a new mechanism that involves H-bonding Pd-O(H)···H-CF 3 and nucleophilic attack of the promoter on the metal, followed by a push-pull-type collapse of the resultant five-coordinate Pd(II) intermediate via a polar transition state.
